Bryan Larsen

Osteopathic Medicine Center, Des Moines University, United States of America

Dr Larsen received his PhD in microbiology from the University of Iowa, 1976. His research combines study of mechanisms of microbial pathogenicity with an interest in infectious diseases relevant to obstetrics and gynecology. His research programs have included both basic laboratory science and clinical research studies and have spanned topics from endocrine mechanisms of normal flora control, to pharmacokinetics of antimicrobial drugs in pregnancy, to the discovery of immunomodulating substances of microbial origin. He has presented his research at many national and international meetings and has been a visiting professor in China and Germany. Current research areas include Medical Informatics, Microbial virulence regulation, Probiotic mechanisms and Nutraceuticals in diabetes control.

Dr Larsen has had over 130 manuscripts and book chapters published as well as a microbiology text commissioned by the Council of Resident Education for Obstetrics and Gynecology. He has received funding from the National Institutes of Health and many pharmaceutical companies and was the recipient of the Johnson & Johnson Focused Giving Award. He sits on the editorial board of the Annals of Clinical & Laboratory Science and reviews manuscripts for many clinical and basic science journals. He previously served as the chairperson of the City-wide Institutional Review Board, which provides ethical and scientific review for clinical studies conducted in multiple hospitals in Des Moines.

Currently he is the Dean for University Research and Biomedical Graduate Studies, and Professor of Microbiology and of Obstetrics and Gynecology at DMU where he maintains an active research program in addition to teaching and administrative duties. Professional associations include the American Society for Microbiology, International Infectious Disease Society for Obstetrics and Gynecology, Infectious Disease Society of America and the Association of Clinical Scientists.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Women's Health > Gynecologic Inflammation & Infections (since 11 November 2005)

All recent recommendations

• 3.0
  Probiotics for preventing preterm labour.
  Recommended by Bryan Larsen
  
• 3.0
  The frequency and significance of intraamniotic inflammation in patients with cervical insufficiency.
  Recommended by Bryan Larsen
  
• 3.2
  Population seroprevalence of human papillomavirus types 6, 11, 16, and 18 in men, women, and children in Australia.
  Recommended by Lars Ostergaard with Christian Wejse, Bryan Larsen
  
• 3.0
  Early repeated infections with Trichomonas vaginalis among HIV-positive and HIV-negative women.
  Recommended by Bryan Larsen
  
• 3.0
  Nutritional indicators of adverse pregnancy outcomes and mother-to-child transmission of HIV among HIV-infected women.
  Recommended by Bryan Larsen
  
• 3.2
  Herpes simplex virus viremia during primary genital infection.
  Recommended by Bryan Larsen, Lars Ostergaard with Christian Wejse
  
• 3.0
  Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic.
  Recommended by Bryan Larsen
  
• 3.0
  Bacterial Vaginosis, Not HIV, Is Primarily Responsible for Increased Vaginal Concentrations of Proinflammatory Cytokines.
  Recommended by Bryan Larsen
  
• 4.8
  Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial.
  Recommended by Anne Buve, Bryan Larsen
  
• 3.0
  Prevalence and abundance of uncultivated Megasphaera-like bacteria in the human vaginal environment.
  Recommended by Bryan Larsen
  
• 6.0
  HPV vaccination: an opportunity for good and the potential for harm.
  Recommended by Bryan Larsen
  
• 3.0
  The relationship between periodontal disease, bacterial vaginosis, and preterm birth.
  Recommended by Bryan Larsen
  
• 3.0
  An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole.
  Recommended by Bryan Larsen
  
• 3.0
  Effect of biofilm phenotype on resistance of Gardnerella vaginalis to hydrogen peroxide and lactic acid.
  Recommended by Bryan Larsen
  
• 3.0
  Detection of bacteria in placental tissues obtained from extremely low gestational age neonates.
  Recommended by Bryan Larsen
  
• 3.0
  Human decidual cell Toll-like receptor signaling in response to endotoxin: the effect of progestins.
  Recommended by Bryan Larsen
  
• 3.0
  Detection of a microbial biofilm in intraamniotic infection.
  Recommended by Bryan Larsen
  
• 3.0
  Maternal infection and risk of preeclampsia: systematic review and metaanalysis.
  Recommended by Bryan Larsen
  
• 3.2
  Clinical trial of interconceptional antibiotics to prevent preterm birth: subgroup analyses and possible adverse antibiotic-microbial interaction.
  Recommended by Torsten Reinheimer, Bryan Larsen
  
• 3.0
  Familial patterns of preterm delivery: maternal and fetal contributions.
  Recommended by Bryan Larsen
  
• 3.0
  A population study of the contribution of medical comorbidity to the risk of prematurity in blacks.
  Recommended by Bryan Larsen
  
• 6.0
  Evaluation of fetal and maternal genetic variation in the progesterone receptor gene for contributions to preterm birth.
  Recommended by Bryan Larsen
  
• 3.0
  The association between Trichomonas vaginalis infection and level of vaginal lactobacilli, in nonpregnant women.
  Recommended by Bryan Larsen
  
• 3.0
  Selective testing criteria for gonorrhea among young women screened for Chlamydial infection: contribution of race and geographic prevalence.
  Recommended by Bryan Larsen
  
• 3.0
  Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis.
  Recommended by Bryan Larsen
  
• 3.0
  Rapid characterization of the normal and disturbed vaginal microbiota by application of 16S rRNA gene terminal RFLP fingerprinting.
  Recommended by Bryan Larsen
  
• 3.0
  Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births.
  Recommended by Bryan Larsen
  
• 3.0
  Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis.
  Recommended by Bryan Larsen
  
• 3.0
  Characterization of prostaglandin E2 production by Candida albicans.
  Recommended by Bryan Larsen
  
• 3.2
  Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women.
  Recommended by Bryan Larsen, Rosanna Peeling with Jane Cunningham
  
• 6.0
  Use of DNA tests for human Papillomavirus infection by US clinicians, 2004.
  Recommended by Bryan Larsen
  
• 3.0
  Preterm low birth weight and maternal periodontal status: a meta-analysis.
  Recommended by Bryan Larsen
  
• 3.0
  Modulation of vaginal immune response among pregnant women with bacterial vaginosis by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, and yeast.
  Recommended by Bryan Larsen
  
• 6.0
  Preterm birth among African American and white women with a lifelong residence in high-income Chicago neighborhoods: an exploratory study.
  Recommended by Bryan Larsen
  
• 3.0
  Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection.
  Recommended by Bryan Larsen
  
• 3.0
  Complications of pregnancy and transplacental transmission of relapsing-fever borreliosis.
  Recommended by Bryan Larsen
  
• 3.0
  Selectin polymorphisms and perinatal morbidity in low-birthweight infants.
  Recommended by Bryan Larsen
  
• 3.0
  The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy.
  Recommended by Bryan Larsen
  
• 3.0
  Multiplex measurement of cytokine/receptor gene polymorphisms and interaction between interleukin-10 (-1082) genotype and chorioamnionitis in extreme preterm delivery.
  Recommended by Bryan Larsen
  
• 3.0
  Variation in vaginal immune parameters and microbial hydrolytic enzymes in bacterial vaginosis positive pregnant women with and without Mobiluncus species.
  Recommended by Bryan Larsen
  
• 3.0
  Role for dendritic cells in immunoregulation during experimental vaginal candidiasis.
  Recommended by Bryan Larsen
  
• 6.0
  High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence.
  Recommended by Bryan Larsen
  
• 3.0
  Local and systemic cytokine levels in relation to changes in vaginal flora.
  Recommended by Bryan Larsen
  
• 3.0
  A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes.
  Recommended by Bryan Larsen
  
• 6.0
  Genetic variation associated with preterm birth: a HuGE review.
  Recommended by Bryan Larsen