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Browse > Critical Care & Emergency Medicine > Sepsis & Multiple Organ Failure in Critical Care
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Must Read
F1000 Factor 6.0

New Finding
 Distinct hemodynamic patterns of septic shock at presentation to pediatric intensive care.
Brierley J, Peters MJ
Pediatrics 2008 Oct 122(4):752-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francis Leclerc
Evaluated 26 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.
Cavassani KA, Ishii M, …, Hogaboam CM, Kunkel SL
J Exp Med 2008 Oct 27 205(11):2609-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Diego Kyburz
Evaluated 20 Nov 2008


Must Read
F1000 Factor 6.0

Hypothesis
 TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice.
Spiller S, Elson G, …, Wagner H, Kirschning CJ
J Exp Med 2008 Aug 4 205(8):1747-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hong Wei Chu
Evaluated 23 Oct 2008

Must Read
F1000 Factor 4.8

Confirmation
 The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis.
Jones AE, Brown MD, …, Kline JA, Emergency Medicine Shock Research Network investigators
Crit Care Med 2008 Oct 36(10):2734-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Luecke / Walter Hasibeder
First evaluation 14 Oct 2008 | Latest evaluation 6 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Controversial
 Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock?
Vallée F, Vallet B, …, Fourcade O, Genestal M
Intensive Care Med 2008 Jul 8 [abstract on PubMed] [related articles] [full text]
Selected by | Martin Dunser
Evaluated 8 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
Wurfel MM, Gordon AC, …, Russell JA, Martin TR
Am J Respir Crit Care Med 2008 Oct 1 178(7):710-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joseph Mizgerd
Evaluated 7 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Role of nuclear factor-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failure.
Schmidt C, Höcherl K, Kurt B, Bucher M
Crit Care Med 2008 Aug 36(8):2363-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Walter Hasibeder
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.2

Confirmation
Hypothesis
Controversial
 Randomized clinical trial of activated protein C for the treatment of acute lung injury.
Liu KD, Levitt J, …, Eisner MD, Matthay MA
Am J Respir Crit Care Med 2008 Sep 15 178(6):618-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Claude Guerin with Ghislain Flandreau / Albertus Beishuizen with Alexander Cornet
First evaluation 23 Sep 2008 | Latest evaluation 26 Sep 2008

Recommended
F1000 Factor 3.0

Controversial
 Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock.
Wheeler DS, Devarajan P, …, Cvijanovich N, Wong HR
Crit Care Med 2008 Apr 36(4):1297-303 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Joannidis with Marianne Schmid
Evaluated 18 Sep 2008

Must Read
F1000 Factor 4.8

Confirmation
Refutation
 Early mortality in patients with community-acquired pneumonia: causes and risk factors.
Garcia-Vidal C, Fernández-Sabé N, …, Manresa F, Gudiol F
Eur Respir J 2008 Sep 32(3):733-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mathias Pletz / Klaus Dalhoff with Petra Heyer
First evaluation 15 Sep 2008 | Latest evaluation 14 Nov 2008


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