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Must Read
F1000 Factor 6.0

New Finding
Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis.
Millonig G, Reimann FM, …, Seitz HK, Mueller S
Hepatology 2008 Nov 48(5):1718-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan A Dranoff
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Effect of a time-dependent colonoscopic withdrawal protocol on adenoma detection during screening colonoscopy.
Barclay RL, Vicari JJ, Greenlaw RL
Clin Gastroenterol Hepatol 2008 Oct 6(10):1091-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Waqar Qureshi
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice.
Hasselblatt P, Gresh L, …, Guinea-Viniegra J, Wagner EF
Oncogene 2008 Oct 23 27(47):6102-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharon DeMorrow
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.
Ge L, Wang J, …, Li BL, Song BL
Cell Metab 2008 Jun 7(6):508-19 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Piero Portincasa
Evaluated 15 Oct 2008


Must Read
F1000 Factor 6.4

Confirmation
New Finding
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
Omenetti A, Porrello A, …, Schuppan D, Diehl AM
J Clin Invest 2008 Oct 1 118(10):3331-3342 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Frank Strutz / Frank Lammert with Susanne Weber
First evaluation 26 Sep 2008 | Latest evaluation 24 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones.
Wang HH, Portincasa P, …, Uribe M, Wang DQ
Gastroenterology 2008 Jun 134(7):2101-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rahul Kuver
Evaluated 24 Sep 2008

Exceptional
F1000 Factor 8.0

Confirmation
New Finding
Tech Advance
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.
Bochkis IM, Rubins NE, …, Friedman JR, Kaestner KH
Nat Med 2008 Aug 14(8):828-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Meenakshisundaram Ananthanarayanan / Marc Jeschke with Katsuhiro Kita
First evaluation 23 Sep 2008 | Latest evaluation 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma.
Nishino R, Honda M, …, Nakanuma Y, Kaneko S
J Hepatol 2008 Aug 49(2):207-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Domenico Alvaro
Evaluated 22 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
Medical Treatment of Primary Sclerosing Cholangitis: A Role for Novel Bile Acids and other (post-)Transcriptional Modulators?
Beuers U, Kullak-Ublick GA, …, Rauws ER, Rust C
Clin Rev Allergy Immunol 2008 Aug 28 [abstract on PubMed] [related articles] [full text]
Selected by | William Balistreri
Evaluated 19 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Combined EUS with FNA and ERCP for the evaluation of patients with obstructive jaundice from presumed pancreatic malignancy.
Ross WA, Wasan SM, …, Prindiville T, Lee JH
Gastrointest Endosc 2008 Sep 68(3):461-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Subhas Banerjee
Evaluated 17 Sep 2008


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