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Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization.
Sundling C, Schön K, …, Karlsson Hedestam GB, Lycke NY
J Gen Virol 2008 Dec 89(Pt 12):2954-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Luigi Buonaguro
Evaluated 1 Dec 2008

Exceptional
F1000 Factor 9.0
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Hypothesis
 Early Antiretroviral Therapy and Mortality among HIV-Infected Infants.
Violari A, Cotton MF, …, McIntyre JA, the CHER Study Team
N Engl J Med 2008 Nov 20 359(21):2233-2244 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kayvon Modjarrad with Sana Dastgheyb
Evaluated 27 Nov 2008

Must Read
F1000 Factor 4.8

Confirmation
New Finding
 Activation of a dendritic cell-T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells.
Perreau M, Pantaleo G, Kremer EJ
J Exp Med 2008 Nov 3 [abstract on PubMed] [related articles] [full text]
Selected by | Scott Sieg with Nicholas Funderburg / Paul Goepfert
First evaluation 13 Nov 2008 | Latest evaluation 18 Nov 2008


Recommended
F1000 Factor 3.0

New Finding
 Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-Dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission.
Church JD, Omer SB, …, Jackson JB, Eshleman SH
J Infect Dis 2008 Oct 1 198(7):1075-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heather Jaspan
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

Controversial
 No major differences in the functional profile of HIV Gag and Nef-specific CD8+ responses between long-term nonprogressors and typical progressors.
López M, Soriano V, …, González-Lahoz J, Benito JM
AIDS Res Hum Retroviruses 2008 Sep 24(9):1185-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Holden Maecker
Evaluated 24 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.
Reynolds MR, Weiler AM, …, Koff WC, Watkins DI
J Exp Med 2008 Oct 6 [abstract on PubMed] [related articles] [full text]
Selected by | Derya Unutmaz
Evaluated 15 Oct 2008

Recommended
F1000 Factor 3.2

Confirmation
New Finding
 Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.
Mandl JN, Barry AP, …, Staprans SI, Feinberg MB
Nat Med 2008 Oct 14(10):1077-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Guido Silvestri / Genoveffa Franchini with Shari Gordon
First evaluation 15 Oct 2008 | Latest evaluation 3 Nov 2008


Recommended
F1000 Factor 3.0

Confirmation
 Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults.
Mark KE, Wald A, …, Huang ML, Corey L
J Infect Dis 2008 Oct 15 198(8):1141-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lars Ostergaard with Christian Wejse
Evaluated 14 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Profiling the Specificity of Neutralizing Antibodies in a Large Panel of HIV-1 Plasmas from Subtype B and C Chronic Infections.
Binley JM, Lybarger EA, …, Montefiori DC, Mascola JR
J Virol 2008 Sep 24 [abstract on PubMed] [related articles] [full text]
Selected by | Leo Stamatatos
Evaluated 8 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs.
Shen L, Peterson S, …, Acosta EP, Siliciano RF
Nat Med 2008 Jul 14(7):762-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jason Brenchley
Evaluated 6 Oct 2008



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