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Must Read
F1000 Factor 6.0

New Finding
Alemtuzumab vs. interferon beta-1a in early multiple sclerosis.
The CAMMS223 Trial Investigators, Coles AJ, …, Norris K, Tandon PK
N Engl J Med 2008 Oct 23 359:1786-801 [abstract on PubMed] [related articles] [order article]
Selected by | Richard Ransohoff with Paolo Muraro
Evaluated 24 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale.
Bakshi R, Neema M, …, Guttmann CR, Weiner HL
Arch Neurol 2008 Nov 65(11):1449-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Franz Fazekas with Christian Enzinger
Evaluated 24 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis.
Lonigro A, Devaux JJ
Brain 2008 Oct 25 [abstract on PubMed] [related articles] [full text]
Selected by | Kazim Sheikh with Helmar Lehmann
Evaluated 24 Nov 2008


Must Read
F1000 Factor 6.0

New Finding
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study.
Segal BM, Constantinescu CS, …, Kasper LH, Ustekinumab MS Investigators
Lancet Neurol 2008 Sep 7(9):796-804 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roland Martin with Manuel Friese
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Gray matter atrophy in multiple sclerosis: a longitudinal study.
Fisher E, Lee JC, Nakamura K, Rudick RA
Ann Neurol 2008 Sep 64(3):255-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marco Rovaris
Evaluated 7 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2.
Hinson SR, Roemer SF, …, Pittock SJ, Lennon VA
J Exp Med 2008 Oct 27 205(11):2473-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charlotte Teunissen
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
Kidd BA, Ho PP, …, Steinman L, Robinson WH
Arthritis Res Ther 2008 Sep 30 10(5):R119 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rene Toes with Leendert Trouw
Evaluated 3 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training.
Lo AC, Triche EW
Neurorehabil Neural Repair 2008 Nov-Dec 22(6):661-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Ruff
Evaluated 3 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.
Han MH, Hwang SI, …, Han DK, Steinman L
Nature 2008 Feb 28 451(7182):1076-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valder Arruda
Evaluated 3 Nov 2008


Recommended
F1000 Factor 3.0

Confirmation
Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab.
Martin MD, Cravens PD, …, Kleinschmidt-Demasters BK, Stüve O
Arch Neurol 2008 Oct 13 [abstract on PubMed] [related articles] [full text]
Selected by | Timothy Vollmer
Evaluated 20 Oct 2008


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