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Must Read
F1000 Factor 6.0

Confirmation
 Phase III, Double-Blind, Randomized Study Comparing Lapatinib Plus Paclitaxel With Placebo Plus Paclitaxel As First-Line Treatment for Metastatic Breast Cancer.
Di Leo A, Gomez HL, …, Finn RS, Press MF
J Clin Oncol 2008 Dec 1 26(34):5544-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carmelo Bengala
Evaluated 1 Dec 2008

Must Read
F1000 Factor 6.0

Confirmation
 Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups.
Strauss GM, Herndon JE, …, Vokes EE, Green MR
J Clin Oncol 2008 Nov 1 26(31):5043-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jack West
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
 Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial.
Palumbo A, Bringhen S, …, Cavo M, Boccadoro M
Blood 2008 Oct 15 112(8):3107-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arati Rao
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma.
Tepmongkol S, Keelawat S, Honsawek S, Ruangvejvorachai P
Thyroid 2008 Jul 18(7):697-704 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antonio Bianco with Denise Armellini
Evaluated 25 Nov 2008

Must Read
F1000 Factor 6.4
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Confirmation
New Finding
 K-ras mutations and benefit from cetuximab in advanced colorectal cancer.
Karapetis CS, Khambata-Ford S, …, Moore MJ, Zalcberg JR
N Engl J Med 2008 Oct 23 359(17):1757-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nicola Normanno with Antonella De Luca / Jeffrey Evans
Evaluated 25 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Phase III trial of consolidation therapy with yttrium-90-ibritumomab tiuxetan compared with no additional therapy after first remission in advanced follicular lymphoma.
Morschhauser F, Radford J, …, Kuhlmann J, Hagenbeek A
J Clin Oncol 2008 Nov 10 26(32):5156-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nicolas Mounier
Evaluated 21 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic.
Cragg MS, Jansen ES, …, Strasser A, Scott CL
J Clin Invest 2008 Nov 118(11):3651-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin Leverkus
Evaluated 21 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
 Rituximab combined with chemotherapy and interferon in follicular lymphoma patients: results of the GELA-GOELAMS FL2000 study.
Salles G, Mounier N, …, Xerri L, Foussard C
Blood 2008 Sep 17 [abstract on PubMed] [related articles] [full text]
Selected by | Armando López-Guillermo
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial.
Eisen T, Oudard S, …, Escudier B, TARGET Study Group
J Natl Cancer Inst 2008 Oct 15 100(20):1454-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David M Nanus
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Prognostic nomogram for sunitinib in patients with metastatic renal cell carcinoma.
Motzer RJ, Bukowski RM, …, Baum CM, Kattan MW
Cancer 2008 Oct 1 113(7):1552-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David M Nanus
Evaluated 19 Nov 2008


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