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Must Read
F1000 Factor 4.8

Hypothesis
New Finding
 Seeding and propagation of untransformed mouse mammary cells in the lung.
Podsypanina K, Du YC, …, Hambardzumyan D, Varmus H
Science 2008 Sep 26 321(5897):1841-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Larry Suva / Christos Sotiriou with Michail Ignatiadis
First evaluation 7 Nov 2008 | Latest evaluation 11 Nov 2008


Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
Controversial
 EWS-FLI1 Induces Developmental Abnormalities and Accelerates Sarcoma Formation in a Transgenic Mouse Model.
Lin PP, Pandey MK, …, Parant JM, Lozano G
Cancer Res 2008 Nov 1 68(21):8968-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 5 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Detection and characterization of CD133+ cancer stem cells in human solid tumours.
Tirino V, Desiderio V, …, De Rosa A, Papaccio G
PLoS ONE 2008 3(10):e3469 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Lessnick
Evaluated 3 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 The prognostic value of tumor markers in newly diagnosed patients with primary central nervous system germ cell tumors.
Kim A, Ji L, …, Sposto R, Finlay JL
Pediatr Blood Cancer 2008 Dec 51(6):768-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Nicholson with Matthew Murray
Evaluated 27 Oct 2008

Must Read
F1000 Factor 6.4

New Finding
 Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome.
Bercovich D, Ganmore I, …, Green AR, Izraeli S
Lancet 2008 Oct 25 372(9648):1484-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jason Gotlib with Stephen Oh / Neyssa Marina with Maureen M O'Brien
First evaluation 16 Oct 2008 | Latest evaluation 7 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors.
Potikyan G, France KA, …, Nelson SF, Denny CT
Lab Invest 2008 Oct 6 [abstract on PubMed] [related articles] [full text]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.
Wang X, Arai S, …, Glass CK, Kurokawa R
Nature 2008 Jul 3 454(7200):126-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008


Recommended
F1000 Factor 3.0

Confirmation
 Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
Paulussen M, Craft AW, …, Jürgens H, European Intergroup Cooperative Ewing's Sarcoma Study-92
J Clin Oncol 2008 Sep 20 26(27):4385-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression.
Douglas D, Hsu JH, …, Triche TJ, Lawlor ER
Cancer Res 2008 Aug 15 68(16):6507-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

Controversial
 Preradiation chemotherapy may improve survival in pediatric diffuse intrinsic brainstem gliomas: final results of BSG 98 prospective trial.
Frappaz D, Schell M, …, Szathmari A, Carrie C
Neuro Oncol 2008 Aug 10(4):599-607 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eric Bouffet
Evaluated 3 Oct 2008


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