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Browse > Oncology > Sarcomas
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Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Multiple primary sporadic gastrointestinal stromal tumors in the adult: an underestimated entity.
Gasparotto D, Rossi S, …, Dei Tos AP, Maestro R
Clin Cancer Res 2008 Sep 15 14(18):5715-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Florence Duffaud
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.
Lazar AJ, Tuvin D, …, Pollock RE, Lev D
Am J Pathol 2008 Nov 173(5):1518-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Riedel
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
Controversial
 EWS-FLI1 Induces Developmental Abnormalities and Accelerates Sarcoma Formation in a Transgenic Mouse Model.
Lin PP, Pandey MK, …, Parant JM, Lozano G
Cancer Res 2008 Nov 1 68(21):8968-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 5 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Detection and characterization of CD133+ cancer stem cells in human solid tumours.
Tirino V, Desiderio V, …, De Rosa A, Papaccio G
PLoS ONE 2008 3(10):e3469 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Lessnick
Evaluated 3 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.
Matushansky I, Hernando E, …, Cordon-Cardo C, Maki RG
Am J Pathol 2008 Apr 172(4):1069-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Tap
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Addiction to elevated insulin-like growth factor i receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.
Cao L, Yu Y, …, Khanna C, Helman LJ
Cancer Res 2008 Oct 1 68(19):8039-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Katie Janeway
Evaluated 20 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors.
Potikyan G, France KA, …, Nelson SF, Denny CT
Lab Invest 2008 Oct 6 [abstract on PubMed] [related articles] [full text]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.
Wang X, Arai S, …, Glass CK, Kurokawa R
Nature 2008 Jul 3 454(7200):126-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008


Recommended
F1000 Factor 3.0

Confirmation
 Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
Paulussen M, Craft AW, …, Jürgens H, European Intergroup Cooperative Ewing's Sarcoma Study-92
J Clin Oncol 2008 Sep 20 26(27):4385-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression.
Douglas D, Hsu JH, …, Triche TJ, Lawlor ER
Cancer Res 2008 Aug 15 68(16):6507-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 10 Oct 2008


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