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Recommended
F1000 Factor 3.0

New Finding
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
Pickford F, Masliah E, …, Levine B, Wyss-Coray T
J Clin Invest 2008 Jun 118(6):2190-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elio Scarpini with Daniela Galimberti
Evaluated 3 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Selective changes of resting-state networks in individuals at risk for Alzheimer's disease.
Sorg C, Riedl V, …, Zimmer C, Wohlschläger AM
Proc Natl Acad Sci U S A 2007 Nov 20 104(47):18760-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Levy with Emmanuelle Volle
Evaluated 2 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Controversial
Refutation
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial.
Holmes C, Boche D, …, Zotova E, Nicoll JA
Lancet 2008 Jul 19 372(9634):216-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark A. Smith
Evaluated 1 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction.
Chu KO, Wang CC, …, Choy KW, Pang CP
J Chromatogr B Analyt Technol Biomed Life Sci 2004 Oct 25 810(2):187-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephane Bastianetto
Evaluated 1 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice.
Mastrangelo MA, Bowers WJ
BMC Neurosci 2008 Aug 12 9(1):81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yuan Luo
Evaluated 22 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Halle A, Hornung V, …, Moore KJ, Golenbock DT
Nat Immunol 2008 Aug 9(8):857-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michel Goldman
Evaluated 20 Aug 2008


Must Read
F1000 Factor 6.0

New Finding
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
Riemersma-van der Lek RF, Swaab DF, …, Hoogendijk WJ, Van Someren EJ
JAMA 2008 Jun 11 299(22):2642-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Kaufer
Evaluated 14 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Human microglial cells synthesize albumin in brain.
Ahn SM, Byun K, …, Simpson RJ, Lee B
PLoS ONE 2008 3(7):e2829 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Charlotte Teunissen
Evaluated 12 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
A randomized, double-blind, placebo-controlled study of aripiprazole for the treatment of psychosis in nursing home patients with Alzheimer disease.
Streim JE, Porsteinsson AP, …, McQuade R, Carson WH
Am J Geriatr Psychiatry 2008 Jul 16(7):537-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Steffens
Evaluated 8 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Longitudinal multimodal imaging in mild to moderate Alzheimer's disease: a pilot study with memantine.
Schmidt R, Ropele S, …, Kolassa H, Fazekas F
J Neurol Neurosurg Psychiatry 2008 Jun 27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Brooks with Nicola Pavese
Evaluated 1 Aug 2008


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