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F1000 Factor 6.0

Hypothesis
 Deletional tolerance mediated by extrathymic Aire-expressing cells.
Gardner JM, Devoss JJ, …, Krummel MF, Anderson MS
Science 2008 Aug 8 321(5890):843-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ann Reed with Vaidehi R Chowdhary
Evaluated 28 Aug 2008


Recommended
F1000 Factor 3.0

New Finding
 Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis.
Gosset M, Berenbaum F, …, Tahiri K, Jacques C
Arthritis Rheum 2008 May 58(5):1399-409 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ulf Mueller-Ladner with Elena Neumann
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.
Niewold TB, Kelly JA, …, Harley JB, Crow MK
Arthritis Rheum 2008 Aug 58(8):2481-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gary Firestein with Susan E Sweeney
Evaluated 28 Aug 2008

Exceptional
F1000 Factor 9.0

New Finding
 Pyogenic bacterial infections in humans with MyD88 deficiency.
von Bernuth H, Picard C, …, Puel A, Casanova JL
Science 2008 Aug 1 321(5889):691-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Routes with James Verbsky
Evaluated 28 Aug 2008


Recommended
F1000 Factor 3.0

Hypothesis
 Antiinflammatory effect of peripheral nerve blocks after knee surgery: clinical and biologic evaluation.
Martin F, Martinez V, …, Chauvin M, Fletcher D
Anesthesiology 2008 Sep 109(3):484-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patricia Lavand'homme
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Adalimumab effectively reduces the rate of anterior uveitis flares in patients with active ankylosing spondylitis: results of a prospective open-label study.
Rudwaleit M, Rødevand E, …, Kary S, Kupper H
Ann Rheum Dis 2008 Jul 28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Juergen Braun with Xenofon Baraliakos
Evaluated 27 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 TSLP acts on infiltrating effector T cells to drive allergic skin inflammation.
He R, Oyoshi MK, …, Ziegler SF, Geha RS
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11875-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stefan Wöhrl
Evaluated 27 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques
Cecchinato V, Trindade CJ, Laurence A, Heraud JM
Mucosal Immunology 2008 1:279-288 [full text]
Selected by | Yufei Wang
Evaluated 26 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Chen ML, Yan BS, …, Kuchroo VK, Weiner HL
J Immunol 2008 Jun 1 180(11):7327-37 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen D. Miller with Joseph R Podojil
Evaluated 26 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Tumor regression in cancer patients by very low doses of a T cell-engaging antibody.
Bargou R, Leo E, …, Baeuerle PA, Kufer P
Science 2008 Aug 15 321(5891):974-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mariput Corr
Evaluated 26 Aug 2008


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