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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Association between findings on delayed gadolinium-enhanced magnetic resonance imaging of cartilage and future knee osteoarthritis.
Owman H, Tiderius CJ, …, Nyquist F, Dahlberg LE
Arthritis Rheum 2008 Jun 58(6):1727-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jukka Jurvelin with Simo Saarakkala
Evaluated 1 Dec 2008

Must Read
F1000 Factor 6.0

Tech Advance
High-throughput screening for modulators of mesenchymal stem cell chondrogenesis.
Huang AH, Motlekar NA, …, Shore EM, Mauck RL
Ann Biomed Eng 2008 Nov 36(11):1909-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jason Burdick with Cindy Chung
Evaluated 20 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Lumican inhibits collagen deposition in tissue engineered cartilage.
Kafienah W, Cheung FL, …, Roughley PJ, Hollander AP
Matrix Biol 2008 Jul 27(6):526-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rita Kandel
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
Targeted drug delivery by in vivo coupling to endogenous albumin: an albumin-binding prodrug of methotrexate (MTX) is better than MTX in the treatment of murine collagen-induced arthritis.
Fiehn C, Kratz F, …, Müller-Ladner U, Neumann E
Ann Rheum Dis 2008 Aug 67(8):1188-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Johanne Martel-Pelletier with Christelle Boileau
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
The effect of alendronate on progression of spinal osteophytes and disc-space narrowing.
Neogi T, Nevitt MC, …, Bauer D, Felson DT
Ann Rheum Dis 2008 Oct 67(10):1427-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Tobias with Emma Clark
Evaluated 28 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation.
Charni-Ben Tabassi N, Desmarais S, …, Percival MD, Garnero P
Osteoarthritis Cartilage 2008 Oct 16(10):1183-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yves Henrotin
Evaluated 22 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Development of the vertebral morphogenetic field in the mouse: Interactions between Crossveinless-2 and Twisted Gastrulation.
Zakin L, Metzinger CA, …, Coffinier C, De Robertis EM
Dev Biol 2008 Aug 29 [abstract on PubMed] [related articles] [full text]
Selected by | Linda Sandell with Debabrata Patra
Evaluated 21 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Design of graded biomimetic osteochondral composite scaffolds.
Tampieri A, Sandri M, …, Quarto R, Martin I
Biomaterials 2008 Sep 29(26):3539-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mats Brittberg
Evaluated 15 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
Chang W, Tu C, …, Bikle D, Shoback D
Sci Signal 2008 1(35):ra1 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Fuller
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes.
Yatabe T, Mochizuki S, …, Toyama Y, Okada Y
Ann Rheum Dis 2008 Jul 28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ladislav Senolt with Markéta Lišková
Evaluated 7 Oct 2008


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