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Browse > Rheumatology & Clinical Immunology > Etiology, Pathogenesis & Animal Models of Rheumatic Disease
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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.
Cavassani KA, Ishii M, …, Hogaboam CM, Kunkel SL
J Exp Med 2008 Oct 27 205(11):2609-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Diego Kyburz
Evaluated 20 Nov 2008


Recommended
F1000 Factor 3.0

New Finding
 Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease.
Ioan-Facsinay A, Willemze A, …, Huizinga TW, El-Gabalawy HS
Arthritis Rheum 2008 Oct 58(10):3000-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dirk Elewaut
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
 Trex1 prevents cell-intrinsic initiation of autoimmunity.
Stetson DB, Ko JS, Heidmann T, Medzhitov R
Cell 2008 Aug 22 134(4):587-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roberto Caricchio with Stefania Gallucci
Evaluated 14 Nov 2008


Must Read
F1000 Factor 6.0

New Finding
 Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study.
Segal BM, Constantinescu CS, …, Kasper LH, Ustekinumab MS Investigators
Lancet Neurol 2008 Sep 7(9):796-804 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roland Martin with Manuel Friese
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Controversial
 Sumo-1 function is dispensable in normal mouse development.
Zhang FP, Mikkonen L, …, Thesleff I, Jänne OA
Mol Cell Biol 2008 Sep 28(17):5381-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Pap with Marvin Peters
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
Kidd BA, Ho PP, …, Steinman L, Robinson WH
Arthritis Res Ther 2008 Sep 30 10(5):R119 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rene Toes with Leendert Trouw
Evaluated 3 Nov 2008

Must Read
F1000 Factor 6.4

New Finding
 CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, …, Nomura T, Sakaguchi S
Science 2008 Oct 10 322(5899):271-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ann Reed with Vaidehi R Chowdhary / Gyorgy Nagy
First evaluation 31 Oct 2008 | Latest evaluation 12 Nov 2008


Recommended
F1000 Factor 3.0

New Finding
 Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
Notley CA, Inglis JJ, …, McNamee KE, Williams RO
J Exp Med 2008 Oct 27 205(11):2491-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carlo Chizzolini
Evaluated 30 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Mazzucchelli R, Hixon JA, …, Leonard WJ, Durum SK
Blood 2008 Oct 15 112(8):3283-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Javier Chinen with Usa Tantibhaedhyangkul
Evaluated 28 Oct 2008

Must Read
F1000 Factor 6.5

Hypothesis
New Finding
 Innate immunity and intestinal microbiota in the development of Type 1 diabetes.
Wen L, Ley RE, …, Gordon JI, Chervonsky AV
Nature 2008 Oct 23 455(7216):1109-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philipp M Lepper / Helena Tlaskalova-Hogenova / Kazuhiko Yamamoto with Akiko Okamoto
First evaluation 28 Oct 2008 | Latest evaluation 21 Nov 2008



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