John Sedor

Medicine, Case School of Medicine, United States of America

John Sedor

Academic positions:
- Professor, Medicine and Physiology and Biophysics, Case Western Reserve University
- Vice President, Research MetroHealth System Campus, Case Western Reserve University
- Research Endowment Professorship, Case Western Reserve University, Cleveland, Ohio
- 1991 - 2003 Director, Division of Nephrology & Hypertension, Case Western Reserve University
- 1998 - 2003 Director, O'Brien Renal Research Center, Case Western Reserve University

All industry positions (in last five years):
None declared

Research interests:
The Sedor lab uses genetic and genomic approaches to define mechanisms of progressive CKD. Diabetic nephropathy is a common complication that results in kidney filtration barrier dysfunction and scarring, ultimately culminating in kidney failure and dialysis. Current projects focus on a novel scaffold protein necessary for assembly of proteins required for normal glomerular filtration barrier function and collecting families to identify diabetic nephropathy susceptibility genes using linkage and association approaches.

Any other information:

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Nephrology > Renal Immunology & Pathology (inc. Glomerular Diseases) (since 14 November 2005)

Links

http://www.metrohealthresearch.org/

All recent recommendations

• 3.2
  Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.
  Recommended by Krzysztof Kiryluk, John Sedor
  
• 3.0
  Chromogranin A polymorphisms are associated with hypertensive renal disease.
  Recommended by John Sedor
  
• 10.0
  Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
  Recommended by Ali Gharavi, John Sedor, Susan Quaggin, Jochen Reiser with Clemens Möller
  
• 3.0
  Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies.
  Recommended by John Sedor
  
• 6.6
  Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.
  Recommended by Robert Anderson, Brenda Bucklin, John Sedor
  
• 3.0
  Meta-analysis: the effect of statins on albuminuria.
  Recommended by John Sedor
  
• 3.0
  Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.
  Recommended by John Sedor
  
• 3.2
  Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency.
  Recommended by John Sedor, Peter Stenvinkel
  
• 3.0
  Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis.
  Recommended by John Sedor