Joseph Bidwell

Anatomy & Cell Biology, Indiana University School of Medicine, United States of America

Joseph Bidwell

Academic positions:
- Associate Professor of Anatomy and Cell Biology
- Associate Professor of Peridontics

All industry positions (in last five years):
None declared

Research interests:
Ten million people in the US suffer from osteoporosis, a disease of reduced bone mass and debilitating fractures. Another 30-40 million in this country are at risk for this disease. Parathyroid hormone (PTH) is currently the only FDA-approved drug for osteoporosis that induces new bone growth, however, the molecular mechanisms responsible for this anabolic effect are not understood.

Our laboratory is currently focused on the potential roles of two proteins as mediators of the skeleton’s anabolic response to PTH: nuclear matrix protein 4/ cas interacting zinc finger protein (Nmp4/CIZ) and high mobility group box 1 protein (HMGB1). Both proteins are transcription factors that can leave the confines of the nucleus and act as a signaling molecule in the cytoplasm (Nmp4/CIZ) or as an intercellular pro-inflammatory cytokine (HMGB1). Our preliminary data show that Nmp4/CIZ regulates the magnitude of the skeleton's response to PTH through as of yet undefined actions in osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells). We have recently shown that PTH regulates the release of HMGB1 from osteoblasts and are presently determining how the presence of HMGB1 in the bone microenvironment influences the anabolic response to hormone.

Any other information:

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Rheumatology & Clinical Immunology > Bone Biology, Osteoporosis & Other Diseases of Bone (since 27 April 2007)

Links

http://anatomy.iupui.edu/anatfaculty/bidwell.html

All recent recommendations

• 3.0
  Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study.
  Recommended by Joseph Bidwell
  
• 3.0
  High-Mobility Group Box Proteins Modulate Tumor Necrosis Factor-{alpha} Expression in Osteoclastogenesis via a Novel Deoxyribonucleic Acid Sequence.
  Recommended by Joseph Bidwell
  
• 6.0
  HMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE.
  Recommended by Joseph Bidwell
  
• 3.0
  Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.
  Recommended by Joseph Bidwell
  
• 9.0
  Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium.
  Recommended by Joseph Bidwell
  
• 3.0
  Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions.
  Recommended by Joseph Bidwell
  
• 3.0
  Effects of basic fibroblast growth factor and a prostaglandin E2 receptor subtype 4 agonist on osteoblastogenesis and adipogenesis in aged ovariectomized rats.
  Recommended by Joseph Bidwell