Caroline Owen

Division of Pulmonary/Critical Care Medicine, Brigham and Women's Hospital, United States of America

Caroline Owen is Assistant Professor of Medicine at Harvard Medical School and Assistant Professor of Medicine in the Division of Pulmonary/Critical Care Medicine at Brigham and Women's Hospital.

Her laboratory studies the cell biology and enzyme biochemistry of leukocyte serine proteinases and matrix metalloproteinases (MMPs) and ADAM family members. They also investigate the pathologic roles of MMPs and ADAM family members in lung pathologies including acute lung injury, pulmonary fibrosis, pulmonary emphysema, and asthma.

As well as being a member of numerous professional societies, she is a Fellow of the Royal College of Physicians of Edinburgh, UK, and a member of the Editorial Board of the American Journal of Respiratory Cell and Molecular Biology.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Respiratory Disorders > COPD & Allied Disorders (since 30 November 2005)

Links

http://www.brighamandwomens.org/respiratorydisorders/Faculty/Owen.asp

All recent recommendations

• 3.0
  Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
  Recommended by Caroline Owen with Sylwia P Lonak
  
• 3.0
  Chronic LPS Inhalation Causes Emphysema-like Changes in Mouse Lung that is Associated with Apoptosis.
  Recommended by Caroline Owen with Sylwia P Lonak
  
• 9.6
  Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
  Recommended by Rosalind Smyth, Caroline Owen
  
• 3.0
  Polarized Localization of Epithelial CXCL11 in Chronic Obstructive Pulmonary Disease and Mechanisms of T Cell Egression.
  Recommended by Caroline Owen
  
• 3.0
  Haemophilus influenzae induces neutrophil necrosis: a role in chronic obstructive pulmonary disease?
  Recommended by Caroline Owen
  
• 4.8
  IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
  Recommended by Rubin Tuder, Caroline Owen
  
• 6.0
  Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.
  Recommended by Caroline Owen
  
• 3.0
  Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall.
  Recommended by Caroline Owen
  
• 3.0
  Gefitinib prevents bleomycin-induced lung fibrosis in mice.
  Recommended by Caroline Owen
  
• 3.0
  Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase.
  Recommended by Caroline Owen
  
• 3.0
  Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury.
  Recommended by Caroline Owen
  
• 3.0
  Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
  Recommended by Caroline Owen
  
• 6.0
  Elastin fragments drive disease progression in a murine model of emphysema.
  Recommended by Caroline Owen
  
• 3.0
  NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.
  Recommended by Caroline Owen
  
• 3.0
  Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung.
  Recommended by Caroline Owen