Marilyn Telen

Duke University, United States of America

Marilyn J. Telen

Academic positions:
- Professor and Chief of the Division of Hematology
- Director of the Duke-UNC Comprehensive Sickle Cell Center

All industry positions (in last five years):

Research interests:
Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix.

Recent investigations have focused on the role of Lutheran blood group antigen protein as a laminin receptor and LW blood group antigen protein (ICAM-4) as an integrin receptor in sickle cell erythrocytes. Present studies include (1) investigation of the roles of B-CAM/LU and LW in vaso-occlusion using in vivo models; (2) mapping of the functional domain of the B-CAM/LU laminin receptor, using recombinant proteins; (3) determination of the signaling mechanisms that activate the B-CAM/LU and LW receptors; (4) identification of additional ligands for B-CAM/LU; and (5) interaction of CD44 and B-CAM/LU as adhesion molecules in cancer.

Dr. Telen is also currently the P.I. on a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertensin in sickle cell disease.

Any other information:

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Hematology > Anemias & Hypocellular Marrow Disorders (since 27 November 2006)

All recent recommendations

• 3.0
  Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.
  Recommended by Marilyn Telen
  
• 9.0
  Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype.
  Recommended by Marilyn Telen
  
• 3.0
  Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1.
  Recommended by Marilyn Telen
  
• 3.0
  Phase I study of eptifibatide in patients with sickle cell anaemia.
  Recommended by Marilyn Telen
  
• 3.0
  Prokaryotic versus eukaryotic recombinant Lutheran blood group protein for antibody identification.
  Recommended by Marilyn Telen
  
• 4.8
  Increased adhesion to endothelial cells of erythrocytes from patients with polycythemia vera is mediated by laminin alpha5 chain and Lu/BCAM.
  Recommended by Hans U Lutz, Marilyn Telen
  
• 3.0
  Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells.
  Recommended by Marilyn Telen
  
• 3.0
  Identification of peptide ligands facilitating nanoparticle attachment to erythrocytes.
  Recommended by Marilyn Telen
  
• 6.0
  Sickle cell trait and the risk of venous thromboembolism among blacks.
  Recommended by Marilyn Telen