Mark A. Smith

Institute of Pathology, Case Western Reserve University, United States of America

Dr. Mark A. Smith received his B.Sc. with Honors in Molecular Biology and Biochemistry from Hatfield College, Durham University, England (1986). He went on to earn a Ph.D. in Biochemistry from Nottingham University, England, in 1990 and spent the next two years as a Research Fellow at Sandoz Forschungsinstitut in Vienna, Austria before joining Case Western Reserve University where he is now Professor of Pathology.

Dr. Smith is the recipient of several awards including the Ruth Salta Junior Investigator Achievement Award from the American Health Assistance Foundation, Young Scientist Lectureship Award from the International Society for Neurochemistry, the Nathan Shock New Investigator Award from The Gerontological Society of America, the Zenith Award from the Alzheimer's Association, the Jordi Folch-Pi Award from the American Society of Neurochemistry, and the Hermann-Esterbauer Award from the HNE Society and is a fellow of the American Aging Association. Dr. Smith has also been recognized for his contributions to teaching with, among others, the Outstanding Mentor Award, School of Graduate Studies.

The focus of Dr. Smith’s research involves investigating the pathological mechanism(s) underlying selective neuronal death in neurodegenerative diseases such as Alzheimer’s disease. Dr. Smith’s research involves a variety of techniques ranging from histological to molecular biology to cellular models and encompasses diagnostic, mechanistic, and therapeutic strategies. Current projects are directed towards 1) fundamental metabolic alterations; 2) homeostatic dysregulation of transition metals; 3) signal transduction alterations; and 4) inappropriate re-entry into the cell cycle.

Dr. Smith has authored over 600 peer-reviewed manuscripts and chapters and is recognized as one of the top cited researchers in the fields of Neuroscience & Behavior (http://www.in-cites.com/nobel/2007-neu-top100.html), Alzheimer Disease (http://www.esi-topics.com/alzheimer/authors/b1a.html) and Free Radical Biology (http://www.freeradicalscience.com/labs.php).

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Psychiatry > Alzheimer's Disease (since 28 July 2008)