Gyongyi Horvath

Faculty of Medicine and Faculty of Health Sciences, University of Szeged, Hungary

Research interests: Professor Horvath’s research focuses on how endogenous ligands influence the pain sensitivity and which type of interactions could be observed after coadministration of different endogenous ligands at spinal level.
Her self and her colleagues are particularly interested in the endogenous opioid endomorphin-1 and the NMDA antagonist kynurenic acid.
Complementary research projects are currently addressing the development of new chronic pain models and new technics for pain assessment.
Used are a number of different techniques to address the behavioral aspects of pain mechanisms in rats:
Chronic intrathecal catheterization
Continuous intrathecal microinfusion
tail-flick test
PWd test
Von-Frey test
Weight-load analysis during walk

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Anesthesiology & Pain Management > Pain: Basic Science (since 14 November 2005)

All recent recommendations

• 3.0
  Y1 receptor knockout increases nociception and prevents the anti-allodynic actions of NPY.
  Recommended by Gyongyi Horvath
  
• 3.2
  Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain.
  Recommended by Gyongyi Horvath, Mellar Davis
  
• 6.4
  TRPV1 shows dynamic ionic selectivity during agonist stimulation.
  Recommended by Misha Perouansky, Gyongyi Horvath
  
• 4.9
  Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees.
  Recommended by Johanne Martel-Pelletier with Daniel Lajeunesse, PhD, Gyongyi Horvath, Karin Westlund High with Liping Zhang
  
• 3.0
  Nociception increases during opioid infusion in opioid receptor triple knock-out mice.
  Recommended by Gyongyi Horvath
  
• 3.0
  Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
  Recommended by Gyongyi Horvath
  
• 3.0
  Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior.
  Recommended by Gyongyi Horvath
  
• 4.8
  Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.
  Recommended by Gyongyi Horvath, Claudia Sommer
  
• 6.0
  Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist.
  Recommended by Gyongyi Horvath
  
• 3.0
  Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
  Recommended by Gyongyi Horvath
  
• 3.0
  Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.
  Recommended by Gyongyi Horvath
  
• 3.0
  Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization.
  Recommended by Gyongyi Horvath
  
• 3.0
  Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain.
  Recommended by Gyongyi Horvath
  
• 6.0
  Evidence for a role of CaMKIV in the development of opioid analgesic tolerance.
  Recommended by Gyongyi Horvath
  
• 6.0
  The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.
  Recommended by Gyongyi Horvath
  
• 3.0
  Phospholipase Cbeta1 modulates pain sensitivity, opioid antinociception and opioid tolerance formation.
  Recommended by Gyongyi Horvath
  
• 6.0
  Involvement of spinal glia in tetanically sciatic stimulation-induced bilateral mechanical allodynia in rats.
  Recommended by Gyongyi Horvath
  
• 3.0
  Development and expression of neuropathic pain in CB1 knockout mice.
  Recommended by Gyongyi Horvath
  
• 3.0
  Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.
  Recommended by Gyongyi Horvath
  
• 3.0
  Cyclin-dependent kinase 5 activity regulates pain signaling.
  Recommended by Gyongyi Horvath
  
• 3.0
  Effects of intrathecal anandamide on somatosensory evoked responses in rats.
  Recommended by Gyongyi Horvath
  
• 3.0
  Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation.
  Recommended by Gyongyi Horvath
  
• 6.4
  ORL1 receptor-mediated internalization of N-type calcium channels.
  Recommended by Koichi Noguchi, Gyongyi Horvath
  
• 3.0
  Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.
  Recommended by Gyongyi Horvath
  
• 3.0
  A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833.
  Recommended by Gyongyi Horvath
  
• 3.0
  Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat.
  Recommended by Gyongyi Horvath
  
• 3.0
  CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.
  Recommended by Gyongyi Horvath
  
• 3.0
  Effect of peripheral axotomy on pain-related behavior and dorsal root ganglion neurons excitability in NPY transgenic rats.
  Recommended by Gyongyi Horvath
  
• 3.0
  The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10.
  Recommended by Gyongyi Horvath
  
• 3.0
  Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release.
  Recommended by Gyongyi Horvath
  
• 3.0
  Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla.
  Recommended by Gyongyi Horvath
  
• 3.0
  The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3.
  Recommended by Gyongyi Horvath
  
• 3.0
  TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator.
  Recommended by Gyongyi Horvath
  
• 3.0
  Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice.
  Recommended by Gyongyi Horvath
  
• 3.0
  Involvement of N-methyl-D-aspartate-type glutamate receptor epsilon1 and epsilon4 subunits in tonic inflammatory pain and neuropathic pain.
  Recommended by Gyongyi Horvath
  
• 3.0
  Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
  Recommended by Gyongyi Horvath
  
• 3.0
  Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse.
  Recommended by Gyongyi Horvath