Stuart Forman

Dept. of Anesthesia & Critical Care, Massachusetts General Hospital, United States of America

Current Appointments: Associate Professor, Department of Anaesthesia, Harvard Medical School and Associate Anesthetist, Massachusetts General Hospital.

Biography details: BA in Chemistry 1980 Wesleyan University magna cum laude. M.D. 1989 Harvard Medical School (Harvard-MIT Division of Health Sciences and Technology). Ph.D. in Biophysics 1989 Harvard University. Internship in Internal Medicine 1989-90 Beth Israel Hospital, Boston, MA. Residency in Anesthesiology 1990-93 Massachusetts General Hospital, Boston, MA. Postdoctoral Fellowship in Neurobiology 1993-4 in the lab of Prof. Gary Yellen, Harvard Medical School. American Board of Anesthesiology Certification 1994. Foundation for Anesthesia Education and Research Starter Grant 1993. The Medical Foundation/Charles King Trust Fellowship Award 1995. Scientist Development K21 Award (NIH/NIAAA) 1996-2001. Presidential Early Career Award for Scientists and Engineers 2003.

Research interests: Molecular and neurobiological mechanisms of anesthesia, with a focus on the molecular mechanism of anesthetic modulation at nicotinic ACh and GABA-A receptors. Artificial Synapses: combined patch-clamp electrophysiology with ultra-fast concentration-jump. Kinetic modeling of ion channel functions. Awareness During General Anesthesia.

Current Research Funding: NIH R01GM66724 and P01GM58448.
Associations: Biophysical Society, Society for Neuroscience, American Society of Anesthesiologists, Association of University Anesthesiologists.
Contact: saforman@partners.org

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Anesthesiology & Pain Management > Anesthetic Mechanisms (since 14 November 2005)

Links

http://www.etherdome.org/index.html

All recent recommendations

• 3.0
  Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits.
  Recommended by Stuart Forman
  
• 3.0
  Mutations of the GABA-A receptor {alpha}1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
  Recommended by Stuart Forman
  
• 6.0
  Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric modulator.
  Recommended by Stuart Forman
  
• 3.0
  The F-loop of the GABAA receptor gamma 2 subunit contributes to benzodiazepine modulation.
  Recommended by Stuart Forman
  
• 3.0
  Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.
  Recommended by Stuart Forman
  
• 3.2
  Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.
  Recommended by Gregg Homanics, Stuart Forman
  
• 3.0
  Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABAA receptor.
  Recommended by Stuart Forman
  
• 3.0
  The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.
  Recommended by Stuart Forman
  
• 3.0
  Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action.
  Recommended by Stuart Forman
  
• 3.0
  Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors.
  Recommended by Stuart Forman