Alan Nurden

Laboratoire de Pathologie Cellulaire de l'Hémostase, University of Bordeaux, France

Alan T Nurden

Academic positions:
- Research Director and scientific co-ordinator of the Reference Centre for Inherited Diseases of Platelets

All industry positions (in last five years):

Research interests:
Dr Nurden's lifelong career interest has been characterising rare hereditary bleeding syndromes resulting from quantitative or qualitative abnormalities of platelet function and/or production. He has participated in the elucidation of the molecular pathways responsible for platelet adhesion and platelet aggregation, and of the mode of action of anti-thrombotic drugs that inhibit platelet receptors. His recent involvements had been the characterization of the P2Y12, ADP receptor and its pathology and is currently improving diagnosis and molecular characterisation of defects in signaling pathways of platelets. He is also looking for ways to improve patient care in a group with rare diseases and this has proved to be of value to our understanding of cardiovascular disease and its therapy.

Any other information:
- 2001 received a "Distinguished Career Award" of the International Society on Thrombosis and Haemostasis
- 2002 awarded the Prix Danièle Hermann of the French Foundation for Cardiovascular Research of the Institut de France
- Member of the Scientific Committee on Platelets of the American Society of hematology, 2002-2004
- Reviewer for 44 scientific journals and author of over 200 publications

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Hematology > Bleeding & Coagulation Disorders (since 10 November 2005)

All recent recommendations

• 6.0
  Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.
  Recommended by Alan Nurden
  
• 3.0
  Heritability of platelet function in families with premature coronary artery disease.
  Recommended by Alan Nurden
  
• 6.0
  Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy.
  Recommended by Alan Nurden
  
• 3.0
  Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro.
  Recommended by Alan Nurden
  
• 6.0
  The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.
  Recommended by Alan Nurden
  
• 9.0
  Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets.
  Recommended by Alan Nurden
  
• 3.0
  Critical role of beta3 integrin in experimental postmenopausal osteoporosis.
  Recommended by Alan Nurden
  
• 3.0
  Effects of estrogen replacement therapies on mouse platelet function and glycoprotein VI levels.
  Recommended by Alan Nurden
  
• 9.0
  Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets.
  Recommended by Alan Nurden