Robert Plenge

Broad Institute of Harvard and Massachusetts Institute of Technology, Brigham and Women's Hospital, United States of America

Robert Plenge, M.D., Ph.D.

Dr. Robert Plenge is an Assistant Professor of Medicine at Harvard Medical School in the Harvard-Partners Center for Genetics & Genomics.  He is also Director of Genetics & Genomics in the Division of Rheumatology, Immunology & Allergy at Brigham and Women’s Hospital, and a Research Scientist at the Broad Institute of MIT and Harvard.

Robert’s research interest is to translate human genetic discoveries to care of patients with common autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).  Because the bottleneck has been the identification gene variants that influence the risk of both RA and SLE, Robert has focused on human genetic studies of disease susceptibility for these diseases.  His work, in close collaborators with scientists from across the world, has more than doubled the number of confirmed gene variants that contribute to risk of RA. His future goals include understanding how newly identified gene variants change the immune system to cause disease and how these variants can be used in the rheumatology clinic to treat patients more effectively.

https://www.i2b2.org/disease/arthritis.html

http://focus.hms.harvard.edu/2007/110907/genomics.shtml

http://www.brighamandwomens.org/research/Rheumatology/Labs/Plenge/default.asp

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Rheumatology & Clinical Immunology > Etiology, Pathogenesis & Animal Models of Rheumatic Disease (since 07 March 2008)

Links

http://harvardscience.harvard.edu/directory/researchers/robert-plenge

All recent recommendations

• 3.0
  Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
  Recommended by Robert Plenge
  
• 8.0
  Multiple genetic loci for bone mineral density and fractures.
  Recommended by Peter Ebeling with Dr Claudia Gagnon, Robert Plenge
  
• 6.0
  Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
  Recommended by Robert Plenge