Riqiang Yan

Department of Neurosciences, Lerner Research Institute, United States of America

We focus our research on the regulated productions of Alzheimer’s amyloid peptides and formation of neuritic plaques.

Specifically, we are interested in understanding the regulation of BACE1, a type I membrane bound aspartyl protease which functions as the b-secretase. We have recently identified RTN/Nogo family members as BACE1 modulators. The roles of these proteins in Alzheimer’s pathogenesis are currently being investigated.

Associations: American Association for Cell Biology; Society for Neuroscience; The American Society for Biochemistry and Molecular Biology.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Psychiatry > Alzheimer's Disease (since 15 November 2005)

Links

http://www.lerner.ccf.org/neurosci/yan/

All recent recommendations

• 6.0
  Substrate-targeting gamma-secretase modulators.
  Recommended by Riqiang Yan
  
• 6.0
  Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.
  Recommended by Riqiang Yan
  
• 6.0
  Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.
  Recommended by Riqiang Yan
  
• 6.6
  Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
  Recommended by Massimo Pandolfo, Frank LaFerla, Riqiang Yan
  
• 3.0
  Biogenesis of gamma-secretase early in the secretory pathway.
  Recommended by Riqiang Yan
  
• 3.0
  Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization.
  Recommended by Riqiang Yan
  
• 6.0
  Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
  Recommended by Riqiang Yan
  
• 3.0
  Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
  Recommended by Riqiang Yan
  
• 3.0
  A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.
  Recommended by Riqiang Yan
  
• 4.9
  APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
  Recommended by Luc Buee, Riqiang Yan, Florence Thibaut