Philippe Le Bouteiller

Hopital Purpan, Bat A, INSERM U563, Toulouse, France

Director of Research at the French National Institute of Health and Medical Research (INSERM), Toulouse, France. PhD in Biology of Reproduction in the laboratories of Pr. M. Panigel and Dr. G. Voisin, Paris, France. Postdoctoral Fellow, Clinical Research Center, Harrow, UK (Dr. G.L. Asherson), Center of Immunology of Marseille-Luminy, France (Dr. F. Kourislky) and Department of Biology, Yale University, USA laboratory of Pr. F. Ruddle. Team leader “HLA-G, Immunity and gestation”, Toulouse, France (1992).

Research interests: Functions of the classical and nonclassical HLA class I molecules during pregnancy. Role of soluble and membrane-bound HLA-G isoforms in human embryonic implantation, pregnancy outcome, and placental development (immunological and angiogenic functions). Phenotypical and functional analysis of human decidual NK cells in normal pregnancies and recurrent spontaneous abortion.

The laboratory uses a number of techniques to address these questions, including multicolor flow cytometry and cell sorting, confocal microscopy, laser micro dissection, immunohistochemistry, ELISA, chemioluminescence, CBA cytokine measurement, RT-PCR, DNA sequencing, cellular and bacterial transfections, production of recombinant proteins, murine in vivo models.

My group is member of EMBIC, a European Network of Excellence (Contract n° LSHM-CT-2004-512040).

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Women's Health > Reproductive Immunology (since 30 January 2006)

Links

http://www.toulouse.inserm.fr

All recent recommendations

• 8.2
  Endometrial NK cells are special immature cells that await pregnancy.
  Recommended by Vikki Abrahams, Lois Salamonsen, Philippe Le Bouteiller, Judith Bulmer with Gendie E Lash
  
• 6.0
  Mistaken notions about natural killer cells.
  Recommended by Philippe Le Bouteiller
  
• 4.8
  Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy.
  Recommended by Philippe Le Bouteiller, Barbara Anne Croy
  
• 3.0
  The trafficking of natural killer cells.
  Recommended by Philippe Le Bouteiller
  
• 3.0
  Structural studies on HLA-G: implications for ligand and receptor binding.
  Recommended by Philippe Le Bouteiller
  
• 6.0
  Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.
  Recommended by Philippe Le Bouteiller
  
• 4.8
  Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
  Recommended by Philippe Le Bouteiller, John Aplin
  
• 9.9
  Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.
  Recommended by Vikki Abrahams, Ashley Moffett, Philippe Le Bouteiller, Jeffrey Pollard
  
• 3.0
  Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation.
  Recommended by Philippe Le Bouteiller
  
• 3.2
  Activation of NK cells by an endocytosed receptor for soluble HLA-G.
  Recommended by Philippe Le Bouteiller, Margaret Petroff