Dominique Langin

Laboratoire de recherches sur les obésités, INSERM U858, I2MR, IFR31, France

Dominique Langin is Director of Research at the INSERM Unit U858.

His research focuses on the study of lipid and energy metabolism of adipose tissue and skeletal muscle in humans; humoral and nutritional control of adipocyte secretions of active molecules on the biology of the adipose cell; the physiology of the adipose tissue; and their involvement in the obesity-type 2 diabetes relationships. He is also interested in the role, function and regulation of extracellular matrix components during the differentiation of human fat cell precursors and delineation of cardiac and sympathetic nervous system adaptations to elucidate pathological mechanisms at the origin of cardiac alterations observed in obese patients.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Diabetes & Endocrinology > Diabetes & Obesity (since 09 November 2005)

All recent recommendations

• 6.0
  Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.
  Recommended by Dominique Langin
  
• 6.0
  Genetics of gene expression and its effect on disease.
  Recommended by Dominique Langin
  
• 3.0
  The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.
  Recommended by Dominique Langin
  
• 3.0
  Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.
  Recommended by Dominique Langin
  
• 6.0
  Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.
  Recommended by Dominique Langin
  
• 3.0
  Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.
  Recommended by Dominique Langin
  
• 3.0
  Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation.
  Recommended by Dominique Langin
  
• 6.4
  Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
  Recommended by Dominique Langin, Luca Persani
  
• 3.0
  The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.
  Recommended by Dominique Langin