Charles Emala

Dept of Anesthesiology, Columbia University Medical Center, United States of America

Research Summary
Dr. Emala's research involves the study of cellular signal transduction pathways in smooth muscle cells.

An understanding of both normal and disease-altered signaling pathways is sought in conditions such as asthma, preterm labor and congestive heart failure. Particular focus is given to G protein coupled pathways with emphasis on the expression and regulation of the enzyme adenylyl cyclase, the generator of cyclic AMP, a ubiquitous cellular second messenger. A second area of focus is the interplay between anesthetic agents and airway tone. Specifically, the interaction of neuromuscular blocking agents with muscarinic, histamine and tachykinin receptors in airway muscle and the nerves that innervate airway muscle is under investigation. Tissue and cell culture models from both humans and animals are utilized employing cellular and molecular biological techniques.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Anesthesiology & Pain Management > Airway/Respiratory Physiology (since 27 February 2008)

Links

http://www.cumc.columbia.edu/research/Faculty_Profiles/profiles/emala_cw.htm

All recent recommendations

• 6.0
  A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
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• 3.0
  Clinical pharmacology of GW280430A in humans.
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