Boris Bastian

Departments of Dermatology and Pathology, UCSF, United States of America

Boris C Bastian, MD

Academic positions:
Associate Professor in Residence, Departments of Dermatology and Pathology, UCSF.

1982-1988 Medicine, Ludwig-Maximilian-University of Munich, Germany; 1989-94 Residency, Dermatology, Dept. of Dermatology, University of Würzburg, Germany;
1997-99 Postdoctoral Fellowship, Cancer Genetics Group, Cancer Center at UCSF; 1999-2004 Assistant Clinical Professor, Dept. of Dermatology and Pathology, UCSF.

Research Interest:
Genetic analysis of skin cancer. Our research focuses on the genetic characteristics of melanocytic neoplasia with an emphasis on classification, diagnosis, and susceptibility. We use a variety of genomic approaches to identify genes involved in progression and susceptibility to skin cancer. One focus is the development of genetic markers that can be used to distinguish benign from malignant melanocytic neoplasms and detect minimal residual disease. We are also very interested in studying the basis of the increased susceptibility of organ transplant recipients to developing squamous cell carcinoma of the skin.

Acknowledgements:
Various members of the group assist me with making evaluations for Faculty of 1000: Jürgen Bauer, Vladimir Bezrookove, John Curtin, Vijay Joseph, Katie Ridd, and Amaya Viros.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Dermatology > Skin Cancers (inc. Melanoma & Lymphoma) (since 11 November 2005)

Links

http://cc.ucsf.edu/people/bastian_boris.html

All recent recommendations

• 3.2
  ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.
  Recommended by Boris Bastian, Akira Ishiko
  
• 3.0
  A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
  Recommended by Boris Bastian
  
• 9.7
  Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.
  Recommended by Barry Nelkin, Boris Bastian, Mina Yaar
  
• 6.5
  Central role of p53 in the suntan response and pathologic hyperpigmentation.
  Recommended by Boris Bastian, Mina Yaar, Thomas Schwarz
  
• 6.5
  Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning.
  Recommended by Boris Bastian, Marjan Garmyn, Mina Yaar
  
• 3.0
  Oncogenic BRAF is required for tumor growth and maintenance in melanoma models.
  Recommended by Boris Bastian
  
• 3.0
  Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and uveal melanomas detected by fluorescence in situ hybridization.
  Recommended by Boris Bastian
  
• 6.4
  SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.
  Recommended by Boris Bastian, Rodney Sinclair
  
• 3.0
  Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
  Recommended by Boris Bastian