Lois Salamonsen

Uterine Biology Laboratory, Prince Henry's Institute of Medical Research, Australia

- Head of Uterine Biology at Prince Henry’s Institute
- Principal Research Fellow of the National Health and Medical Research Council of Australia
- Honorary Professor: Monash University Dept of Obstetrics and Gynaecology
- President: Society for Reproductive Biology (2003-2006)

The mission of Professor Salamonsen’s research group is to improve women’s reproductive health. Studies aim to improve contraceptive choices for women and to develop strategies to overcome infertility, endometrial bleeding problems and endometriosis.

The group focuses on the biology of the endometrium, particularly as it relates to the process of embryo implantation; thus the work has long-term implications for fertility and infertility. Other studies are examining the remodelling of the uterus, relating to abnormal uterine bleeding and also uterine cancer. Close collaborations with clinical colleagues ensures the clinical relevance of the work in the laboratory.

The laboratory uses state of the art techniques to address these issues including cell culture, immunohistology, enzyme assays, in vivo mouse models (uterine administration of morpholino antisense oligos, models for menstruation and long-term progestin action) laser capture microdissection, gene array analysis, proteomic analyses.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Women's Health > Menstrual Abnormalities & Abnormal Uterine Bleeding (since 14 November 2005)

Links

http://www.phimr.monash.edu.au/uterinebiol.html

All recent recommendations

• 9.0
  VEGF blockade inhibits angiogenesis and reepithelialization of endometrium.
  Recommended by Lois Salamonsen
  
• 8.2
  Endometrial NK cells are special immature cells that await pregnancy.
  Recommended by Vikki Abrahams, Lois Salamonsen, Philippe Le Bouteiller, Judith Bulmer with Gendie E Lash
  
• 3.0
  beta-HCG/LH receptor (beta-HCG/LH-R) expression in eutopic endometrium and endometriotic implants: evidence for beta-HCG sensitivity of endometriosis.
  Recommended by Lois Salamonsen
  
• 3.2
  The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium.
  Recommended by Lois Salamonsen, Alistair Williams
  
• 9.0
  Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis.
  Recommended by Lois Salamonsen
  
• 3.0
  Quantitative cellular and molecular analysis of the effect of progesterone withdrawal in a murine model of decidualization.
  Recommended by Lois Salamonsen
  
• 4.9
  Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice.
  Recommended by Lois Salamonsen, Asgerally Fazleabas, Patrick Groothuis
  
• 3.0
  Gene expression profiling of mid to late secretory phase endometrial biopsies from women with menstrual complaint.
  Recommended by Lois Salamonsen
  
• 3.0
  Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell.
  Recommended by Lois Salamonsen
  
• 3.0
  Reduced levels of VEGF-A and MMP-2 and MMP-9 activity and increased TNF-alpha in menstrual endometrium and effluent in women with menorrhagia.
  Recommended by Lois Salamonsen