Lars Rogge

Immunoregulation Laboratory, Institut Pasteur, Department of Immunology, France

Lars Rogge

Academic positions:
- Director of the Immunoregulation Unit, Department of Immunology, Institut Pasteur, Paris

All industry positions (in last five years):
- None

Research interests:
- Differentiation of naïve CD4+ T lymphocytes into functionally distinct T cell subsets is essential for efficient immune responses against different types of pathogens. On the other hand, polarized effector CD4+ cells are known to play critical roles in the pathogenesis of various immunopathologies, such as autoimmune diseases, allergies and asthma. This indicates T helper cell differentiation must be tightly controlled and that therapeutic modulation of immune responses may have an impact on human diseases.

- Our lab investigates the molecular mechanisms that control the differentiation and function of human T helper cell subsets and analyzes their role in the pathogenesis of inflammatory diseases. We study the signaling pathways, epigenetic modifications and genetic networks involved in T helper cell differentiation and the contribution of distinct T cell subsets in human autoimmune pathologies.

Thoughts on Faculty of 1000 Medicine:
- I think that F1000 Medicine is an efficient tool to keep up-to-date with progress in my field of interest. Furthermore, the condensed form of presentation allows me to rapidly “scan” advances in other areas.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Rheumatology & Clinical Immunology > Biomarkers of Rheumatic Disease (since 14 November 2005)

All recent recommendations

• 4.9
  IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.
  Recommended by Wim van den Berg with Marije Koenders, Frank Nestle with Gayathri K Perera , Lars Rogge
  
• 6.7
  Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
  Recommended by Joseph Mizgerd, Lars Rogge, Jonathan Dyer, Michelle Lowes with Kristine E Nograles
  
• 6.0
  T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.
  Recommended by Lars Rogge
  
• 4.8
  Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
  Recommended by Carlo Chizzolini, Lars Rogge
  
• 6.5
  A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
  Recommended by Jack Satsangi, Eduard Stange, Lars Rogge
  
• 3.0
  A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.
  Recommended by Lars Rogge
  
• 6.0
  The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
  Recommended by Lars Rogge
  
• 6.0
  A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
  Recommended by Lars Rogge
  
• 6.0
  Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.
  Recommended by Lars Rogge