Luc Buee

Directeur de Recherches CNRS, INSERM U837, France

Acknowledgements: Various members of the group assist me with making evaluations for Faculty of 1000: Marie-Christine Galas, Marie Gompel, Malika Hamdane and Nicolas Sergeant.

Areas of interest in research:
*Programmed cell death
*Brain disorders with an emphasis on Alzheimer’s disease
*Brain cytoskeleton.
*Microtubule-associated Tau proteins

The laboratory is mainly interested in the mechanisms of neuronal death in neurodegenerative disorders. The laboratory mainly works on Alzheimer’s disease and related disorders. Its areas of expertise are proteomic analyses of the human brain, peripheral and central biomarkers of neurodegenerative disorders, and development of experimental models of Alzheimer’s disease.

Other activities: Coordinator of the National Brain Awareness Week in Lille, France; Since 2001, Scientific Review Board of the Institute for the Study of Aging, New York; Since 1998, Scientific Review Board of the France Alzheimer Association; Since 1999, Editorial Board, Lettre des Neurosciences, French Society for Neuroscience, Since 2004, Chief-Editor.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Psychiatry > Alzheimer's Disease (since 11 November 2005)

Links

http://www.lille.inserm.fr/

All recent recommendations

• 6.0
  Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
  Recommended by Luc Buee with Nicolas Sergeant
  
• 3.0
  Neuron-specific recombination by Cre recombinase inserted into the murine tau locus.
  Recommended by Luc Buee
  
• 3.0
  Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry.
  Recommended by Luc Buee
  
• 3.0
  Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody.
  Recommended by Luc Buee
  
• 3.0
  Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
  Recommended by Luc Buee
  
• 6.0
  Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.
  Recommended by Luc Buee
  
• 4.9
  APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
  Recommended by Luc Buee, Riqiang Yan, Florence Thibaut