Irfan Rahman

Department of Environmental Medicine, University of Rochester Medical Center, United States of America

Irfan Rahman is Associate Professor of Environmental Medicine at the Department of Environmental Medicine (Lung Biology and Disease Program), University of Rochester Medical Center.

He has a dedicated research program to understand the cellular and molecular mechanisms of the pathogenesis of COPD and the potential benefit of therapeutic interventions. He has spent over 15 years studying the lung cellular and molecular responses to inhaled toxicants. Dr Rahman’s main research interests include understanding the epigenetics (chromatin remodeling), NF-kB regulation, and oxidant/antioxidant imbalance in smokers and patients with asthma and COPD; non-invasive detection and development of biomarkers of oxidative stress and inflammation in COPD; cellular and molecular redox mechanisms of airway inflammation; and molecular mechanisms of regulation of glutathione synthesis in lung inflammation/COPD.

Dr Rahman is an ad-hoc member of the National Institutes of Health/NCI special emphasis study section panel, National Research Council of Canada and on the program committee roster of the respiratory cellular and molecular biology section of the American Thoracic Society. He is an Associate Editor (North America) of the International Journal of COPD and the Journal of Biochemistry and Molecular Biology. He is also on the Editorial Board of Respiratory Research, Inflammation & Allergy-Drug Targets, Antioxidants and Redox Signaling, Current Respiratory Medicine Reviews, and Open Respiratory Medicine Journal. Dr. Rahman is the author of over one hundred original publications in prestigious internationally renowed peer-reviewed journals, and has been invited to write chapters in reference books and editorials in journals.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Respiratory Disorders > COPD & Allied Disorders (since 14 November 2005)

Links

http://www2.envmed.rochester.edu/envmed/tox/faculty/irfan_rahman.html

All recent recommendations

• 9.0
  Decline in NRF2 Regulated Antioxidants in COPD Lungs due to Loss of its Positive Regulator DJ-1.
  Recommended by Irfan Rahman with Indika Edirisinghe
  
• 3.0
  SUPEROXIDE DISMUTASE PROTECTS AGAINST APOPTOSIS AND ALVEOLAR ENLARGEMENT INDUCED BY CERAMIDE.
  Recommended by Irfan Rahman with Hongwei Yao
  
• 3.0
  PDE4 inhibitor (GPD-1116) markedly attenuates the development of cigarette smoke-induced emphysema in senescence accelerated mice P1 strain.
  Recommended by Irfan Rahman with Dr Hongwei Yao
  
• 3.0
  E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.
  Recommended by Irfan Rahman with David Adenuga
  
• 6.0
  Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
  Recommended by Irfan Rahman
  
• 3.0
  Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation.
  Recommended by Irfan Rahman
  
• 3.0
  Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice.
  Recommended by Irfan Rahman
  
• 3.0
  Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
  Recommended by Irfan Rahman