David Adams

Liver Research Group, MRC Centre for Immune Regulation, University of Birmingham, United Kingdom

David Adams is professor of Hepatology and a group leader in the MRC Centre for Immune Regulation at the University of Birmingham.  He is also director of the NIHR Biomedical Research Unit for Liver disease at the Queen Elizabeth Hospital. 

His clinical interests are transplant hepatology and autoimmune liver disease.  Laboratory research interests are focused on mechanisms of immune-mediated liver disease and leucocyte trafficking.  After initial training in hepatology in Birmingham he continued his immunology training with Dr Stephen Shaw at the Experimental Immunology Branch of the National Cancer Institute at the National Institutes of Health, Bethesda, USA. 

He is on the editorial boards of several international journals and currently Associate Editor of Transplant International and Clinical Science.  He was made a Fellow of the Academy of Medical Sciences in 2000.

Any competing interests declared are displayed with individual evaluations.

Faculty Member: Gastroenterology & Hepatology > Liver Biology & Pathobiology (since 11 November 2005)

Links

http://medsciences.bham.ac.uk/departments/liver/

All recent recommendations

• 3.0
  Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells.
  Recommended by David Adams
  
• 6.0
  Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection.
  Recommended by David Adams
  
• 3.0
  Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells.
  Recommended by David Adams
  
• 6.0
  Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.
  Recommended by David Adams
  
• 3.0
  Dendritic cells are required for effective cross-presentation in the murine liver.
  Recommended by David Adams
  
• 3.0
  Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.
  Recommended by David Adams
  
• 3.0
  Pressure loading and ethanol exposure differentially modulate rat hepatic stellate cell activation.
  Recommended by David Adams
  
• 3.0
  THE LIVER SINUSOIDAL ENDOTHELIAL CELL: A CELL TYPE OF CONTROVERSIAL AND CONFUSING IDENTITY.
  Recommended by David Adams
  
• 3.0
  The liver in celiac disease.
  Recommended by David Adams
  
• 3.0
  Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: its implications in lymphocyte trafficking.
  Recommended by David Adams
  
• 3.0
  Stabilin-2 is involved in lymphocyte adhesion to the hepatic sinusoidal endothelium via the interaction with alphaMbeta2 integrin.
  Recommended by David Adams
  
• 3.0
  Age-related changes in the hepatic microcirculation in mice.
  Recommended by David Adams
  
• 3.0
  Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine.
  Recommended by David Adams
  
• 3.0
  Proangiogenic Cytokines as Hypoxia-Dependent Factors Stimulating Migration of Human Hepatic Stellate Cells.
  Recommended by David Adams
  
• 3.0
  CCR5 Deficiency Drives Enhanced Natural Killer Cell Trafficking to and Activation within the Liver in Murine T Cell-Mediated Hepatitis.
  Recommended by David Adams
  
• 6.0
  DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27.
  Recommended by David Adams
  
• 3.2
  CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.
  Recommended by David Adams, Filippo La Torre
  
• 3.0
  Immune role of hepatic TLR-4 revealed by orthotopic mouse liver transplantation.
  Recommended by David Adams
  
• 3.0
  CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
  Recommended by David Adams
  
• 3.0
  Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity.
  Recommended by David Adams
  
• 3.0
  Lack of chemokine receptor CCR5 promotes murine fulminant liver failure.
  Recommended by David Adams
  
• 3.0
  Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B.
  Recommended by David Adams
  
• 3.0
  Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice.
  Recommended by David Adams
  
• 3.0
  Biliary obstruction selectively expands and activates liver myeloid dendritic cells.
  Recommended by David Adams
  
• 3.0
  Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells.
  Recommended by David Adams
  
• 3.0
  Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere.
  Recommended by David Adams
  
• 6.0
  Complete differentiation of CD8+ T cells activated locally within the transplanted liver.
  Recommended by David Adams
  
• 6.0
  TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice.
  Recommended by David Adams
  
• 3.0
  CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
  Recommended by David Adams