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1: Ann Oncol. 2008 Oct;19(10):1770-3. Epub 2008 Jun 10.
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Combined PET and low-dose, noncontrast CT scanning obviates the need for additional diagnostic contrast-enhanced CT scans in patients undergoing staging or restaging for lymphoma.

Elstrom RL, Leonard JP, Coleman M, Brown RK.

Division of Hematology-Oncology, Department of Medicine, Center for Lymphoma and Myeloma Weill Cornell Medical College and the New York Presbyterian Hospital, New York, NY, USA.

BACKGROUND: Positron emission tomography (PET) is more accurate than computed tomography (CT) in staging and restaging of lymphoma, but both are considered necessary. Increasingly, PET is carried out with a low-dose CT scan. Many patients undergo both PET/CT and standard diagnostic CT. The clinical utility of performing both studies in patients with lymphoma was evaluated. PATIENTS AND METHODS: Patients with lymphoma who underwent concurrent PET/CT and diagnostic CT (a scan pair) were identified, and findings detected in either scan but not both were documented. Discrepancies were considered significant if they were related to either lymphoma or another disease process which potentially required intervention. RESULTS: Eighty-seven scan pairs were identified. PET/CT detected additional lesions over diagnostic CT in 30 patients, of which 11 demonstrated increased clinical stage. Lymphoma therapy changed based on PET/CT in two patients, and one occult rectal cancer was detected. In contrast, diagnostic CT detected five relevant findings, including two incidental findings (venous thrombosis) and three patients with splenic lesions, none of which could be confirmed as lymphoma. No patient had change of stage or lymphoma therapy based on diagnostic CT. CONCLUSION: In our series, diagnostic CT did not add value to staging or restaging of lymphoma when carried out concurrently with PET/CT.

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PMID: 18550578 [PubMed - indexed for MEDLINE]