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1: Psychosomatics. 2008 Jul-Aug;49(4):309-16.
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Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction.

Huffman JC, Smith FA, Blais MA, Taylor AM, Januzzi JL, Fricchione GL.

Massachusetts General Hospital, 55 Fruit Street/Warren 1220C, Boston, MA 02114, USA. jhuffman@partners.org

BACKGROUND: Depression (MDD) and anxiety have been associated with negative long-term outcomes among patients with acute myocardial infarction (MI). OBJECTIVE: The objective of the study was to determine whether MDD and anxiety preceding MI were associated with in-hospital post-MI cardiac complications. METHOD: Subjects (N=129) underwent psychiatric interviews within 72 hours of MI and were evaluated for five in-hospital cardiac complications (recurrent ischemia, ventricular arrhythmia, ventricular arrhythmia requiring intervention, congestive heart failure, and reinfarction). RESULTS: Current (pre-MI) MDD was a significant and independent predictor of all complications except recurrent ischemia on multivariate regression analysis. In contrast, pre-MI anxiety was not associated with complications. CONCLUSION: These findings underscore the importance of identifying and treating MDD in post-MI patients and those at risk for MI.

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PMID: 18621936 [PubMed - indexed for MEDLINE]