Your browser version may not work well with NCBI's Web applications. More information here...
1: Antimicrob Agents Chemother. 2008 Oct 20. [Epub ahead of print]
Related Articles, Links
Click here to read Click here to read
Posaconazole Mono- or Combination Therapy for the Treatment of Murine Zygomycosis.

Ibrahim AS, Gebremariam T, Schwartz JA, Edwards JE Jr, Spellberg B.

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California; and the David Geffen School of Medicine at UCLA, Los Angeles, California; Charles River Laboratories, Davis, California.

We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.

PMID: 18936190 [PubMed - as supplied by publisher]