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1: J Clin Microbiol. 2009 Jan;47(1):249-51. Epub 2008 Nov 19.
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Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan.

Sheu SM, Hung KH, Sheu BS, Yang HB, Wu JJ.

Institutes of Basic Medical Sciences, National Cheng Kung University, College of Medicine, No. 1, University Road, Tainan 701, Taiwan.

The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGITSSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the i1-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

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PMID: 19020071 [PubMed - in process]