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 ALL TIME TOP 10 BY F1000 FACTOR | ALL OF MEDICINE | calculated on 4 July 2008

All Time Top 10 By F1000 Factors are generated every day using papers added to F1000 Medicine since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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1
Exceptional
F1000 Factor 11.5
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Confirmation
Hypothesis
New Finding
Controversial
Refutation
 Anesthesia awareness and the bispectral index.
Avidan MS, Zhang L, …, Jacobsohn E, Evers AS
N Engl J Med 2008 Mar 13 358(11):1097-108 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vesna Jevtovic-Todorovic / Philippa Newfield / Beverley Orser / Emery Brown / Harald Groeben / Benedikt Pannen / Manfred Seeberger / Alain Borgeat / Lynda Wells / Dhanesh Gupta / Alex Sia with Serene Leo / Paul Barash / Michael O'Connor / Masahiko Kawaguchi
Dissenters | Albert Dahan with Elise Sarton / Ville Heikki Kalervo Jantti with Seppo Alahuhta
Author Response | Avidan MS, Zhang L, Burnside BA, Finkel KJ, Searleman AC, Selvidge JA, Saager L, Turner MS, Rao S, Bottros M, Hantler C, Jacobsohn E, Evers AS. B-Unaware Trial Group / Avidan et al. [2] / Avidan et al. [3] / Avidan et al. [4] / Avidan et al. [5] / Avidan et al. [6] / Avidan et al. [7] / Avidan et al. [8] / Avidan et al. [9] / Avidan et al. [10] / Avidan et al. [11]
First evaluation 18 Mar 2008 | Latest evaluation 11 Jun 2008

 
2
Exceptional
F1000 Factor 11.2

Confirmation
Hypothesis
New Finding
Tech Advance
 Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.
Binshtok AM, Bean BP, Woolf CJ
Nature 2007 Oct 4 449(7162):607-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Misha Perouansky / Nanna Finnerup / Hugh Hemmings / Emery Brown / Helge Eilers / David Archer / Cheryl Stucky with Daniel Vilceanu / Michael Schaefer
First evaluation 23 Oct 2007 | Latest evaluation 13 Mar 2008

 
3
Exceptional
F1000 Factor 10.7
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Confirmation
New Finding
 Treatment of hypertension in patients 80 years of age or older.
Beckett NS, Peters R, …, Bulpitt CJ, HYVET Study Group
N Engl J Med 2008 May 1 358(18):1887-98 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Deepak Bhatt with Dharam Kumbhani / Ramachandran S. Vasan / Jerome Fleg / Annemarie Hennessy / Ernesto Schiffrin / Wilbert Aronow / Kazuomi Kario with Joji Ishikawa
First evaluation 14 Apr 2008 | Latest evaluation 3 Jun 2008
 
4
Exceptional
F1000 Factor 10.2
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Confirmation
Hypothesis
New Finding
Controversial
 Comparison of two fluid-management strategies in acute lung injury.
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, …, Hite RD, Harabin AL
N Engl J Med 2006 Jun 15 354(24):2564-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lynne Warner Stevenson / Jacques Lacroix / Greg Martin / Michael Gropper / Jacob Sznajder
First evaluation 10 Aug 2006 | Latest evaluation 22 May 2007
 
5
Exceptional
F1000 Factor 10.1

New Finding
Tech Advance
 TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Seki E, De Minicis S, …, Brenner DA, Schwabe RF
Nat Med 2007 Nov 13(11):1324-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ralf Weiskirchen with Falko Drews / Rebecca Wells with Zhaodong Li / Philipp M Lepper / Steven Dooley
First evaluation 27 Nov 2007 | Latest evaluation 13 Dec 2007
 
6
Exceptional
F1000 Factor 10.0
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Confirmation
Hypothesis
New Finding
Controversial
Refutation
 Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury.
The VA/NIH Acute Renal Failure Trial Network
N Engl J Med 2008 May 20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Achim Joerres / Andrew Davenport / John Laffey / Greg Martin
First evaluation 2 Jun 2008 | Latest evaluation 4 Jun 2008
 
7
Exceptional
F1000 Factor 10.0

Confirmation
New Finding
Controversial
 Telmisartan, ramipril, or both in patients at high risk for vascular events.
ONTARGET Investigators, Yusuf S, …, Sleight P, Anderson C
N Engl J Med 2008 Apr 10 358(15):1547-59 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Csaba Kovesdy / Sripal Bangalore / Enyu Imai / Ernie Esquivel
First evaluation 15 Apr 2008 | Latest evaluation 14 May 2008
 
8
Exceptional
F1000 Factor 10.0
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

Confirmation
New Finding
Controversial
 Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial.
Girard TD, Kress JP, …, Bernard GR, Ely EW
Lancet 2008 Jan 12 371(9607):126-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ognjen Gajic / Christer Sinderby / Paolo Navalesi with Dr Valentina Bergamaschi / Jim O'Brien / Marjolein de Wit
First evaluation 21 Jan 2008 | Latest evaluation 6 May 2008
 
9
Exceptional
F1000 Factor 10.0

Hypothesis
New Finding
 Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Hinkes B, Wiggins RC, …, Nürnberg P, Hildebrandt F
Nat Genet 2006 Dec 38(12):1397-405 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ali Gharavi / John Sedor / Susan Quaggin / Jochen Reiser with Clemens Möller
First evaluation 6 Feb 2007 | Latest evaluation 21 Jan 2008
 
10
Exceptional
F1000 Factor 10.0

Hypothesis
New Finding
 Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, …, Richards WG, Schett G
Nat Med 2007 Feb 13(2):156-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Diego Kyburz / Robert Terkeltaub / Thomas Pap with Marvin A. Peters / Frank Barry
First evaluation 28 Mar 2007 | Latest evaluation 31 May 2007

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