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 ALL TIME TOP 10 BY F1000 FACTOR | Diabetes & Endocrinology | calculated on 1 December 2008

All Time Top 10 By F1000 Factors are generated every day using papers added to F1000 Medicine since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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1
Exceptional
F1000 Factor 9.7

Hypothesis
New Finding
 Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.
Wajapeyee N, Serra RW, …, Mahalingam M, Green MR
Cell 2008 Feb 8 132(3):363-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Nelkin / Boris Bastian / Mina Yaar
First evaluation 4 Mar 2008 | Latest evaluation 11 Mar 2008

 
2
Exceptional
F1000 Factor 9.6

Hypothesis
New Finding
Controversial
 Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi S, Ishii K, …, Takeshita S, Ikeda K
Cell Metab 2007 Jun 5(6):464-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Larry Suva / Daniel Bikle
First evaluation 25 Jun 2007 | Latest evaluation 29 Oct 2007
 
3
Exceptional
F1000 Factor 9.0

New Finding
 AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, …, Shaw RJ, Evans RM
Cell 2008 Aug 8 134(3):405-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Carson
Evaluated 17 Oct 2008

 
4
Exceptional
F1000 Factor 9.0

New Finding
 The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
Chang W, Tu C, …, Bikle D, Shoback D
Sci Signal 2008 1(35):ra1 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Fuller
Evaluated 9 Oct 2008
 
5
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
 Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.
Richards JB, Rivadeneira F, …, Uitterlinden AG, Spector TD
Lancet 2008 May 3 371(9623):1505-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Tobias with Emma Clark
Evaluated 14 Jul 2008
 
6
Exceptional
F1000 Factor 9.0

New Finding
 SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Oishi Y, Manabe I, …, Kadowaki T, Nagai R
Nat Med 2008 Jun 14(6):656-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Zecharia Madar
Evaluated 11 Jun 2008
 
7
Exceptional
F1000 Factor 9.0

Confirmation
 Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential.
Koperek O, Scheuba C, …, Niederle B, Kaserer K
Histopathology 2008 Apr 52(5):623-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | JWM Hoeppener
Evaluated 6 Jun 2008
 
8
Exceptional
F1000 Factor 9.0

New Finding
 Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma.
Jazdzewski K, Murray EL, …, Schoenberg DR, de la Chapelle A
Proc Natl Acad Sci U S A 2008 May 20 105(20):7269-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gilbert Cote
Evaluated 5 Jun 2008
 
9
Exceptional
F1000 Factor 9.0

New Finding
 Endocrine disruptors and the thyroid gland--a combined in vitro and in vivo analysis of potential new biomarkers.
Schmutzler C, Gotthardt I, …, Wuttke W, Köhrle J
Environ Health Perspect 2007 Dec 115 Suppl 1:77-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ulla Feldt-Rasmussen
Evaluated 25 Apr 2008
 
10
Exceptional
F1000 Factor 9.0

New Finding
 Motif module map reveals enforcement of aging by continual NF-kappaB activity.
Adler AS, Sinha S, …, Segal E, Chang HY
Genes Dev 2007 Dec 15 21(24):3244-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Carson
Evaluated 12 Mar 2008


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