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 ALL TIME TOP 10 BY F1000 FACTOR | Research Methodology | calculated on 1 December 2008

All Time Top 10 By F1000 Factors are generated every day using papers added to F1000 Medicine since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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1
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
 Almost all articles on cancer prognostic markers report statistically significant results.
Kyzas PA, Denaxa-Kyza D, Ioannidis JP
Eur J Cancer 2007 Nov 43(17):2559-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Willi Sauerbrei
Evaluated 2 Jul 2008
 
2
Exceptional
F1000 Factor 9.0

Tech Advance
 Use of randomised trials to decide when to monitor response to new treatment.
Bell KJ, Irwig L, Craig JC, Macaskill P
BMJ 2008 Feb 16 336(7640):361-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rob Herbert
Evaluated 16 Apr 2008
 
3
Exceptional
F1000 Factor 9.0

Confirmation
Controversial
 Preventive health care in elderly people needs rethinking.
Mangin D, Sweeney K, Heath I
BMJ 2007 Aug 11 335(7614):285-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erik Buskens
Evaluated 6 Sep 2007
 
4
Exceptional
F1000 Factor 9.0

Confirmation
Hypothesis
New Finding
Tech Advance
 Assessment of medical imaging systems and computer aids: a tutorial review.
Wagner RF, Metz CE, Campbell G
Acad Radiol 2007 Jun 14(6):723-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yulei Jiang
Evaluated 31 Jul 2007
 
5
Exceptional
F1000 Factor 9.0

Tech Advance
Controversial
Refutation
 When should epidemiologic regressions use random coefficients?
Greenland S
Biometrics 2000 Sep 56(3):915-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Harrell
Evaluated 23 Jan 2007
 
6
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
 Surrogate endpoints in clinical trials: definition and operational criteria.
Prentice RL
Stat Med 1989Apr 8(4):431-40 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen Senn
Evaluated 14 Mar 2006
 
7
Exceptional
F1000 Factor 9.0

Tech Advance
Controversial
 Evaluation of experiments with adaptive interim analyses.
Bauer P, Köhne K
Biometrics 1994Dec 50(4):1029-41 [abstract on PubMed] [related articles] [order article]
Selected by | Carl-Fredrik Burman
Evaluated 10 Jan 2006
 
8
Exceptional
F1000 Factor 9.0

New Finding
Controversial
Refutation
 The performance of the two-stage analysis of two-treatment, two-period crossover trials.
Freeman PR
Stat Med 1989Dec 8(12):1421-32 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen Senn
Evaluated 24 Nov 2005
 
9
Exceptional
F1000 Factor 8.0
Articles that inform your practice or change your way of thinking Changes
Clinical Practice

New Finding
Tech Advance
 Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography.
van Belle A, Büller HR, …, Tick LW, Christopher Study Investigators
JAMA 2006 Jan 11 295(2):172-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joshua Fenton / Paul Stein
First evaluation 27 Jan 2006 | Latest evaluation 15 Feb 2006
 
10
Must Read
F1000 Factor 6.8

Confirmation
Hypothesis
New Finding
 Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome.
Kaptchuk TJ, Kelley JM, …, Goldman P, Lembo AJ
BMJ 2008 May 3 336(7651):999-1003 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chris Del Mar / Klaus Bielefeldt / Roberto De Giorgio / Davis Mellar / Mike Cummings
Author Response | Kaptchuk TJ, Kelley JM, Conboy LA, Davis RB, Kerr CE, Jacobson EE, Kirsch I, Schyner RN, Nam BH, Nguyen LT, Park M, Rivers AL, McManus C, Kokkotou E, Drossman DA, Goldman P, Lembo AJ
First evaluation 17 Apr 2008 | Latest evaluation 15 Jul 2008

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