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Breast Diseases: Benign & Malignant
Cancer in the Elderly
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Adrenal Cortex
Gastrointestinal Cancers
Leukemia & Proliferative Disorders of Hematic Cells
Lung Cancer
Lymphomas & Myelomas
Multiple Endocrine Disorders & Neoplasias
Neuro-Oncology
Skin Cancers (inc. Melanoma & Lymphoma)


 ALL TIME TOP 10 BY F1000 FACTOR | Oncology | calculated on 1 December 2008

All Time Top 10 By F1000 Factors are generated every day using papers added to F1000 Medicine since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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1
Exceptional
F1000 Factor 10.2

Confirmation
Hypothesis
New Finding
Tech Advance
 Clonal integration of a polyomavirus in human Merkel cell carcinoma.
Feng H, Shuda M, Chang Y, Moore PS
Science 2008 Feb 22 319(5866):1096-100 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sabine Kohler / Ulrike Blume-Peytavi with Karola Stieler / Isaac Neuhaus / Juergen Becker / Jane Sterling
First evaluation 31 Jan 2008 | Latest evaluation 12 Nov 2008

 
2
Exceptional
F1000 Factor 9.8

Confirmation
New Finding
 The epithelial-mesenchymal transition generates cells with properties of stem cells.
Mani SA, Guo W, …, Yang J, Weinberg RA
Cell 2008 May 16 133(4):704-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nicola Normanno with Antonella De Luca / Carlos Telleria / Larry Suva with Corey O Montgomery
First evaluation 27 Jun 2008 | Latest evaluation 19 Aug 2008

 
3
Exceptional
F1000 Factor 9.7

Hypothesis
New Finding
 Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.
Wajapeyee N, Serra RW, …, Mahalingam M, Green MR
Cell 2008 Feb 8 132(3):363-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Nelkin / Boris Bastian / Mina Yaar
First evaluation 4 Mar 2008 | Latest evaluation 11 Mar 2008

 
4
Exceptional
F1000 Factor 9.6

Confirmation
 Controversies of total mesorectal excision for rectal cancer in elderly patients.
Rutten HJ, den Dulk M, …, van de Velde CJ, Marijnen CA
Lancet Oncol 2008 May 9(5):494-501 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Riccardo Audisio / Filippo La Torre
Author Response | Rutten HJ, den Dulk M, Lemmens VE, van de Velde CJ, Marijnen CA
First evaluation 23 May 2008 | Latest evaluation 11 Jun 2008
 
5
Exceptional
F1000 Factor 9.0

New Finding
 Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.
Wang Z, Smith KS, …, Somervaille TC, Cleary ML
Nature 2008 Sep 17 [abstract on PubMed] [related articles] [full text]
Selected by | Jorg Baesecke
Evaluated 30 Oct 2008
 
6
Exceptional
F1000 Factor 9.0

New Finding
 A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome.
Faderl S, Ravandi F, …, Kwari M, Kantarjian HM
Blood 2008 Sep 1 112(5):1638-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arati Rao
Evaluated 5 Sep 2008
 
7
Exceptional
F1000 Factor 9.0

Confirmation
New Finding
 Colonic crypt organization and tumorigenesis.
Humphries A, Wright NA
Nat Rev Cancer 2008 Jun 8(6):415-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Janusz Jankowski
Evaluated 18 Aug 2008
 
8
Exceptional
F1000 Factor 9.0

Tech Advance
 Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers.
Guix M, Granja Nde M, …, Kelley MC, Arteaga CL
J Clin Oncol 2008 Feb 20 26(6):897-906 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Potter
Evaluated 24 Jul 2008
 
9
Exceptional
F1000 Factor 9.0

New Finding
 Rapid leukocyte migration by integrin-independent flowing and squeezing.
Lämmermann T, Bader BL, …, Fässler R, Sixt M
Nature 2008 May 1 453(7191):51-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Friedl
Evaluated 3 Jul 2008

 
10
Exceptional
F1000 Factor 9.0

Confirmation
New Finding
Tech Advance
 Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Walkley CR, Qudsi R, …, McMahon AP, Orkin SH
Genes Dev 2008 Jun 15 22(12):1662-1676 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Lessnick
Evaluated 24 Jun 2008

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