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  Sections Covered
Biomarkers of Rheumatic Disease
Bone Biology, Osteoporosis & Other Diseases of Bone
Cartilage Biology & Osteoarthritis
Clinical Immunology
Etiology, Pathogenesis & Animal Models of Rheumatic Disease
Imaging of the Musculoskeletal System
Immune & Inflammatory Rheumatic Diseases (inc. Arthritis)
Methods, measurements & outcomes in rheumatic disease
Musculoskeletal Pain & Analgesia
Musculoskeletal Repair & Regeneration
Orthopedics (inc. Sports Injuries)
Related Sections
Bone & Mineral Metabolism
Urticaria, Vasculitis & Connective Tissue Disease


 ALL TIME TOP 10 BY F1000 FACTOR | Rheumatology & Clinical Immunology | calculated on 1 December 2008

All Time Top 10 By F1000 Factors are generated every day using papers added to F1000 Medicine since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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1
Exceptional
F1000 Factor 10.0

Hypothesis
New Finding
 Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, …, Richards WG, Schett G
Nat Med 2007 Feb 13(2):156-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Diego Kyburz / Robert Terkeltaub / Thomas Pap with Marvin A. Peters / Frank Barry
First evaluation 28 Mar 2007 | Latest evaluation 31 May 2007
 
2
Exceptional
F1000 Factor 9.9

Hypothesis
New Finding
 Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis.
Kain R, Exner M, …, Rees AJ, Kerjaschki D
Nat Med 2008 Oct 14(10):1088-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Regele / Charles Pusey with Alan Salama / Cees Kallenberg / Philippe Lesavre
First evaluation 21 Oct 2008 | Latest evaluation 17 Nov 2008
 
3
Exceptional
F1000 Factor 9.8

Hypothesis
New Finding
 BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.
Coull JA, Beggs S, …, Salter MW, De Koninck Y
Nature 2005 Dec 15 438(7070):1017-21 [abstract on PubMed] [related articles] [order article]
Selected by | Hanns Ulrich Zeilhofer / Arthur Craig / Jürgen Sandkühler
First evaluation 13 Jun 2006 | Latest evaluation 17 Aug 2006

 
4
Exceptional
F1000 Factor 9.7

Confirmation
New Finding
 Pyogenic bacterial infections in humans with MyD88 deficiency.
von Bernuth H, Picard C, …, Puel A, Casanova JL
Science 2008 Aug 1 321(5889):691-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Routes with James Verbsky / Shawn Skerrett / Philipp M Lepper
First evaluation 28 Aug 2008 | Latest evaluation 25 Sep 2008

 
5
Exceptional
F1000 Factor 9.7

Hypothesis
New Finding
 Gout-associated uric acid crystals activate the NALP3 inflammasome.
Martinon F, Pétrilli V, …, Tardivel A, Tschopp J
Nature 2006 Mar 9 440(7081):237-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marina Botto / Richard Pope / Robert Terkeltaub
First evaluation 30 Jan 2006 | Latest evaluation 28 Mar 2006
 
6
Exceptional
F1000 Factor 9.6

New Finding
Tech Advance
 Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Takahashi K, Tanabe K, …, Tomoda K, Yamanaka S
Cell 2007 Nov 30 131(5):861-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ulf Mueller-Ladner / Carlos Telleria
First evaluation 18 Jan 2008 | Latest evaluation 30 Jan 2008

 
7
Exceptional
F1000 Factor 9.6

Hypothesis
New Finding
Controversial
 Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi S, Ishii K, …, Takeshita S, Ikeda K
Cell Metab 2007 Jun 5(6):464-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Larry Suva / Daniel Bikle
First evaluation 25 Jun 2007 | Latest evaluation 29 Oct 2007
 
8
Exceptional
F1000 Factor 9.6

Hypothesis
New Finding
 SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes.
Fertleman CR, Baker MD, …, Gardiner RM, Rees M
Neuron 2006 Dec 7 52(5):767-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hanns Ulrich Zeilhofer / Massimo Pandolfo
First evaluation 9 Feb 2007 | Latest evaluation 27 Feb 2007

 
9
Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
 Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human.
Chamberlain G, Wright K, …, Ashton B, Middleton J
PLoS ONE 2008 3(8):e2934 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jan-Thorsten Schantz with Harvey Chim
Evaluated 22 Oct 2008
 
10
Exceptional
F1000 Factor 9.0

Hypothesis
 Mechanisms of the anabolic effects of teriparatide on bone: insight from the treatment of a patient with pycnodysostosis.
Chavassieux P, Asser Karsdal M, …, Boivin G, Delmas PD
J Bone Miner Res 2008 Jul 23(7):1076-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joseph Bidwell
Evaluated 16 Sep 2008

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