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 MOST VIEWED TOP 10 (from all journals) | | calculated on 8 January 2009

The "Most Viewed Top 10 (from all journals)" Top 10 lists are generated every day. The articles are ordered by the number of times an article's evaluation(s) has/have been viewed over the past 30 days.

 browse faculty | show Most Viewed (all journals) Papers in

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1
Exceptional
F1000 Factor 10.2

Hypothesis
New Finding
Tech Advance
Controversial
Novel Drug Target
 Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, …, Johnson TM, Morrison SJ
Nature 2008 Dec 4 456(7222):593-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ze'ev Ronai / Ruth Roberts / Dafna Bar-Sagi with Elda Grabocka / John Lazo
First evaluation 9 Dec 2008 | Latest evaluation 7 Jan 2009

 
2
Exceptional
F1000 Factor 9.0

Confirmation
New Finding
Novel Drug Target
 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
Pollin TI, Damcott CM, …, O'Connell JR, Shuldiner AR
Science 2008 Dec 12 322(5908):1702-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Henry Ginsberg
Evaluated 2 Jan 2009
 
3
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Louvet C, Szot GL, …, Weiss A, Bluestone JA
Proc Natl Acad Sci U S A 2008 Dec 2 105(48):18895-900 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven A. Rosenzweig / Daniel Flynn
First evaluation 8 Dec 2008 | Latest evaluation 12 Dec 2008
 
4
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
 Bleach activates a redox-regulated chaperone by oxidative protein unfolding.
Winter J, Ilbert M, …, Ozcelik D, Jakob U
Cell 2008 Nov 14 135(4):691-701 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Burcham / Bruce Demple
Evaluated 8 Dec 2008
 
5
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Novel Drug Target
 Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system.
Cayrol R, Wosik K, …, Stanimirovic D, Prat A
Nat Immunol 2008 Feb 9(2):137-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Paul Marvar
Evaluated 19 Dec 2008
 
6
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
7
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Krohn R, Raffetseder U, …, Mertens PR, Weber C
Circulation 2007 Oct 16 116(16):1812-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Klaudia Budzyn
Evaluated 20 May 2008
 
8
Exceptional
F1000 Factor 9.0

New Finding
 Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway.
Zhang Q, Hong M, …, Ma J, You G
J Biol Chem 2008 Nov 21 283(47):32570-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lawrence Lash
Evaluated 2 Jan 2009
 
9
Recommended
F1000 Factor 3.0

New Finding
 The prolonged life-span of alveolar macrophages.
Murphy J, Summer R, …, Kotton DN, Fine A
Am J Respir Cell Mol Biol 2008 Apr 38(4):380-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthias Ochs with Christian Mühlfeld
Evaluated 22 Dec 2008
 
10
Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Controversial
Novel Drug Target
 Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis.
Nogueira V, Park Y, …, Unterman T, Hay N
Cancer Cell 2008 Dec 9 14(6):458-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Weber / Frank de Gruijl
First evaluation 2 Jan 2009 | Latest evaluation 7 Jan 2009

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